近期研究发现,神经系统疾病标志物的研究热点主要集中在发现和验证具有诊断和预后价值的分子标记。如注意力缺陷多动障碍研究中,microRNA的异常表达作为潜在生物标志物,揭示了其在疾病诊断中的潜在价值。在肌萎缩侧索硬化症的研究中,通过肌肉活检和组织检测,发现了多种调控异常的分子,包括编码和非编码RNA、蛋白质和代谢物,这些分子可作为疾病早期诊断和进展监测的标志。此外,p75神经生长因子受体的可裂解外细胞域在多种神经退行性疾病中的水平升高,也被视为一种可能的生物标志物。这些发现对于早期诊断、疾病监测及开发针对性治疗方法具有重要意义。为此,选择本刊学者2023-2024年发表的帕金森病发病机制的热点综述文章3篇,推荐读者阅读。
(1) MicroRNAs as potential biomarkers for diagnosis of attention deficit hyperactivity disorder
作为诊断注意缺陷多动障碍潜在生物标记物的微RNA
Bridget Martinez 1, Philip V Peplow 2
1 Department of Pharmacology; Department of Medicine, University of Nevada-Reno, Reno, USA.
2 Department of Anatomy, University of Otago, Dunedin, New Zealand.
引用本文:
Martinez B, Peplow PV. MicroRNAs as potential biomarkers for diagnosis of attention deficit hyperactivity disorder. Neural Regen Res. 2024;19(3):557-562. doi: 10.4103/1673-5374.380880
正文链接:
https://journals.lww.com/nrronline/fulltext/2024/03000/micrornas_as_potential_biomarkers_for_diagnosis_of.28.aspx
(2) Skeletal muscle as a molecular and cellular biomarker of disease progression in amyotrophic lateral sclerosis: a narrative review
骨骼肌作为肌萎缩性脊髓侧索硬化症疾病进展的分子和细胞生物标记物:叙述性综述
Peter H King 1
1Department of Neurology and Center for Neurodegeneration and Experimental Therapeutics, The University of Alabama at Birmingham; Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA.
引用本文:
King PH. Skeletal muscle as a molecular and cellular biomarker of disease progression in amyotrophic lateral sclerosis: a narrative review. Neural Regen Res. 2024;19(4):747-753. doi: 10.4103/1673-5374.382226
正文链接:
https://journals.lww.com/nrronline/fulltext/2024/04000/skeletal_muscle_as_a_molecular_and_cellular.17.aspx
(3) Soluble p75 neurotrophic receptor as a reliable biomarker in neurodegenerative diseases: what is the evidence?
可溶性p75神经营养受体作为神经退行性疾病的可靠生物标记物:证据何在?
Georges Jourdi 1, Samuel Fleury 2, Imane Boukhatem 2, Marie Lordkipanidzé 2
1 Research Center, Montreal Heart Institute; Faculty of Pharmacy, Université de Montréal, Montreal, QC, Canada; Université Paris Cité, INSERM, Innovative Therapies in Haemostasis; Service d'Hématologie Biologique, AP-HP, Hôpital Lariboisière, Paris, France.
2 Research Center, Montreal Heart Institute, Montreal, QC, Canada; Faculty of Pharmacy, Université de Montréal, Montreal, QC, Canada.
引用本文:
Jourdi G, Fleury S, Boukhatem I, Lordkipanidzé M. Soluble p75 neurotrophic receptor as a reliable biomarker in neurodegenerative diseases: what is the evidence? Neural Regen Res. 2024 Mar;19(3):536-541.
正文链接:
https://journals.lww.com/nrronline/fulltext/2024/03000/soluble_p75_neurotrophic_receptor_as_a_reliable.25.aspx
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