Nutrition21|一氧化氮的力量：Nitrosigine®是健康老龄化关键营养！

对于注重健康的成年人来说，他们希望在年老时保持活力和积极的生活方式，了解一氧化氮(NO) 在体内的作用变得越来越重要。在发表的研究中，一氧化氮通常被称为“奇迹分子” [1,2]，它在支持心血管健康、认知功能和整体健康方面发挥着至关重要的作用。

随着一氧化氮背后的科学不断进步，Nutrition21 的 Nitrosigine®已成为卓越的一氧化氮助推器，为那些希望有效支持身体产生一氧化氮的人提供了突破性的选择。

通过这种机制，一氧化氮支持心血管健康和血液循环，同时促进氧气和营养物质输送到工作肌肉。[4]除了血管作用外，一氧化氮还在支持认知功能和大脑健康、[5]促进男性性健康和活力、[6]以及支持全身细胞能量产生方面发挥着重要作用。 [7]

• 与标准 L-精氨酸相比，生物利用度更高

• 吸收迅速（30分钟内）

• 血液精氨酸水平持续升高长达 6 小时

• 与其他一氧化氮增强剂（如瓜氨酸）相比，较低剂量（1.5 克）即可见效

通过支持人体的一氧化氮生成，Nitrosigine 可提供一系列全面的益处。对于心血管健康，它支持健康的血液流动和循环，同时帮助保持灵活、健康的血管。这种改善的循环促进了整个身体的最佳营养输送，支持整体心血管功能。

在身体机能方面，Nitrosigine 可增强活动期间向工作肌肉输送氧气和营养物质。这种支持有助于保持能量水平和活力，让成年人全天保持活跃和精力充沛。最近的一项研究表明，Nitrosigine 可增强工作肌肉的血流量（以充血增加为衡量标准），并在连续几天服用时提高感知能量水平。[21]

认知功能也受益于 Nitrosigine 的 NO 促进作用。[22-24]通过支持大脑的健康血流，它可以促进思维敏锐度和注意力，同时帮助维持认知能力。随着我们年龄的增长和寻求保持思维敏锐度，这种认知支持变得越来越重要。

对活力的整体影响可能相当显著。Nitrosigine 有助于通过改善全身循环来维持自然能量水平，促进维持积极的生活方式，并帮助成年人在任何年龄都感觉最好。

多年来，我们多次报道过 Nitrosigine，通常是在运动补充剂中。

凭借其在运动应用中的早期成功，Nutrition21 正在将其旗舰成分推向更高的高度并吸引更广泛的消费者群体，并在 2024 年为其赋予了“卓越一氧化氮助推器”的新口号。

Nitrosigine 是一种经过临床研究的专利成分，代表了新一代的一氧化氮支持技术。

其独特的配方以比传统方法更低的剂量提供卓越的生物利用度和有效性，使其成为注重健康的成年人的理想选择，他们希望随着年龄的增长保持活力并保持积极的生活方式。

Nitrosigine 得到多项临床研究的支持并受专利保护，它提供了一种安全有效的方法来促进健康的一氧化氮生成并支持整体健康。

对于那些寻求保持活力并支持健康衰老的人来说，Nitrosigine 是增强一氧化氮生成和促进最佳健康的卓越解决方案。

参考文献：

1. Bell, Susan Givens. “The Story of Nitric Oxide: From Rascally Radical to Miracle Molecule.” Neonatal Network, vol. 23, no. 4, July 2004, pp. 47–51, doi:10.1891/0730-0832.23.4.47. https://connect.springerpub.com/content/sgrnn/23/4/47
2. Maccallini, Cristina, et al. “Advancements in the Research of New Modulators of Nitric Oxide Synthases Activity.” International Journal of Molecular Sciences, vol. 25, no. 15, Mar. 2024, p. 8486, doi:10.3390/ijms25158486. https://pmc.ncbi.nlm.nih.gov/articles/PMC11313090/
3. Bruckdorfer, Richard. “The Basics about Nitric Oxide.” Molecular Aspects of Medicine, vol. 26, no. 1-2, 1 Feb. 2005, pp. 3–31, pubmed.ncbi.nlm.nih.gov/15722113/, doi:10.1016/j.mam.2004.09.002. https://www.sciencedirect.com/science/article/abs/pii/S0098299704000743
4. Loscalzo, Joseph, and Jin. “Vascular Nitric Oxide: Formation and Function.” Journal of Blood Medicine, Aug. 2010, p. 147, www.ncbi.nlm.nih.gov/pmc/articles/PMC3092409/, doi:10.2147/jbm.s7000. https://pmc.ncbi.nlm.nih.gov/articles/PMC3092409/
5. Bon, Christelle L. M., and John Garthwaite. “On the Role of Nitric Oxide in Hippocampal Long-Term Potentiation.” The Journal of Neuroscience, vol. 23, no. 5, 1 Mar. 2003, pp. 1941–1948, doi:10.1523/JNEUROSCI.23-05-01941.2003. https://pmc.ncbi.nlm.nih.gov/articles/PMC6741944/
6. Toda, N, et al. “Nitric Oxide and Penile Erectile Function.” Pharmacology & Therapeutics, vol. 106, no. 2, May 2005, pp. 233–266, doi:10.1016/j.pharmthera.2004.11.011. https://www.sciencedirect.com/science/article/abs/pii/S0163725804002153
7. Pappas, Gregory, et al. “Nitric Oxide Regulation of Cellular Metabolism: Adaptive Tuning of Cellular Energy.” Nitric Oxide, vol. 131, Feb. 2023, pp. 8–17, doi:10.1016/j.niox.2022.11.006. https://pmc.ncbi.nlm.nih.gov/articles/PMC9839556/
8. Gerhard, Marie, et al. “Aging Progressively Impairs Endothelium-Dependent Vasodilation in Forearm Resistance Vessels of Humans.” Hypertension, vol. 27, no. 4, Apr. 1996, pp. 849–853, doi:10.1161/01.hyp.27.4.849. https://www.ahajournals.org/doi/10.1161/01.HYP.27.4.849
9. Torregrossa, Ashley C, et al. “Nitric Oxide and Geriatrics: Implications in Diagnostics and Treatment of the Elderly.” Journal of Geriatric Cardiology : JGC, vol. 8, no. 4, 1 Dec. 2011, pp. 230–242, doi:10.3724/SP.J.1263.2011.00230. https://pmc.ncbi.nlm.nih.gov/articles/PMC3390088/
10. Ahmad, Ashfaq, et al. “Role of Nitric Oxide in the Cardiovascular and Renal Systems.” International Journal of Molecular Sciences, vol. 19, no. 9, 3 Sept. 2018, doi:10.3390/ijms19092605. https://pmc.ncbi.nlm.nih.gov/articles/PMC6164974/
11. Bryan, Nathan S. “Pharmacological Therapies, Lifestyle Choices and Nitric Oxide Deficiency: A Perfect Storm.” Pharmacological Research, vol. 66, no. 6, Dec. 2012, pp. 448–456, doi:10.1016/j.phrs.2012.09.009. https://www.sciencedirect.com/science/article/abs/pii/S1043661812001843
12. Vijaya Juturu V., Komorowski, JR. “Arginine Silicate Inositol Complex and use Thereof.” United States Patent and Trademark Office. U.S. Patent 7576132B2. 18 Aug. 2009. https://patents.google.com/patent/US7576132
13. Kuhlmann, Erven James. “Process for the production of arginine-silicate complex”. The United States Patent and Trademark Office. U.S. Patent 6803456B1. 13 Aug. 2003. https://patents.google.com/patent/US6803456B1/en
14. Castillo, L, et al. “Splanchnic Metabolism of Dietary Arginine in Relation to Nitric Oxide Synthesis in Normal Adult Man.” Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 1, 1 Jan. 1993, pp. 193–197; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC45626/
15. Wu, Guoyao. “Intestinal Mucosal Amino Acid Catabolism.” The Journal of Nutrition, vol. 128, no. 8, 1 Aug. 1998, pp. 1249–1252, 10.1093/jn/128.8.1249; https://academic.oup.com/jn/article/128/8/1249/4722724
16. O’sullivan, D., et al. “Hepatic Zonation of the Catabolism of Arginine and Ornithine in the Perfused Rat Liver.” Biochemical Journal, vol. 330, no. Pt 2, 1 Mar. 1998, p. 627, 10.1042/bj3300627; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1219183/
17. van de Poll, Marcel CG, et al. “Interorgan Amino Acid Exchange in Humans: Consequences for Arginine and Citrulline Metabolism.” The American Journal of Clinical Nutrition, vol. 85, no. 1, 1 Jan. 2007, pp. 167–172, 10.1093/ajcn/85.1.167; https://pubmed.ncbi.nlm.nih.gov/17209193/
18. Kalman, Douglas, et al. “A Clinical Evaluation to Determine the Safety, Pharmacokinetics, and Pharmacodynamics of an Inositol-Stabilized Arginine Silicate Dietary Supplement in Healthy Adult Males.” Clinical Pharmacology: Advances and Applications, Oct. 2015, p. 103, doi:10.2147/cpaa.s84206; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603712/
19. Komorowski, J., et al. Apr. 2016. “A Pharmacokinetic Evaluation of the Duration of Effect of Inositol- Stabilized Arginine Silicate and Arginine Hydrochloride in Healthy Adult Males.” The Journal of the Federation of American Societies for Experimental Biology vol. 30. https://www.fasebj.org/doi/abs/10.1096/fasebj.30.1_supplement.690.17
20. Rogers, Jeffrey M et al. “Acute effects of Nitrosigine and citrulline malate on vasodilation in young adults.” Journal of the International Society of Sports Nutrition vol. 17,1 12. 24 Feb. 2020, doi:10.1186/s12970-020-00343-y; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041093/
21. Greenberg, Danielle, et al. “Inositol-Stabilized Arginine Silicate Reduces Exercise Induced Muscle Damage and Increases Perceived Energy.” Journal of Exercise and Nutrition, vol. 6, no. 1, 1 Mar. 2023, doi:10.53520/jen2023.103141; https://www.journalofexerciseandnutrition.com/index.php/JEN/article/view/141
22. Evans, M. et al. July 2020. “Inositol-Stabilized Arginine Silicate Improves Post Exercise Cognitive Function in Recreationally Active, Healthy Males: A Randomized, Double-Blind, Placebo-Controlled Crossover Study.” Journal of Exercise and Nutrition vol. 3,3; https://www.journalofexerciseandnutrition.com/index.php/JEN/article/view/69 (full-text PDF, 2018 ISSN Poster Presentation, 2018 ISSN Conference Summary)
23. Gills, Joshua L., et al. “Acute Inositol-Stabilized Arginine Silicate Improves Cognitive Outcomes in Healthy Adults.” Nutrients, vol. 13, no. 12, 1 Dec. 2021, 10.3390/nu13124272; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703995/
24. Kalman, Douglas et al. “Randomized Prospective Double-Blind Studies to Evaluate the Cognitive Effects of Inositol-Stabilized Arginine Silicate in Healthy Physically Active Adults.” Nutrients vol. 8,11 736. 18 Nov. 2016, doi:10.3390/nu8110736; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133120/ (2018 ISSN Summary, 2018 ISSN Poster Presentation)