mRNA疫苗的研发趋势

文摘   2024-12-30 12:25   日本  


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About this book

The authoritative guide to the revolutionary concept behind the successful Covid-19 vaccines
In Trends in mRNA Vaccine Research, a team of distinguished researchers delivers a practical and up-to-date discussion of the biochemical and biomedical foundations of mRNA vaccines. They also explore the manufacturing conditions required for successful vaccine development and review recent progress in a variety of medical fields, including vaccines against pathogens like SARS-CoV-2, HIV, plasmodium, Mycobacterium tuberculosis, as well as anticancer vaccines.
Volume highlights include:
  • A historical overview of mRNA vaccine development
  • Immune responses to modified or unmodified mRNA vaccines
  • A description of the different mRNA vaccine platforms
  • Latest data on current mRNA vaccine developments against infectious diseases and cancer
Perfect for medicinal chemists, immunologists, and epidemiologists, Trends in mRNA Vaccine Research will also benefit researchers and scientists working in the pharmaceutical industry, as well as cancer researchers with an interest in vaccine development.

Part I : How mRNA Vaccines Work

A Historical Overview on mRNA Vaccine Development (Pages: 1-27)
Rein Verbeke,  Miffy H.Y. Cheng,  Pieter R. Cullis

Immune Responses to mRNA Vaccine (Pages: 29-68)

Jean-Yves Exposito,  Claire Monge,  Danielle C. Arruda,  Bernard Verrier


Modified or Unmodified mRNA Vaccines? – The Biochemistry of Pseudouridine and mRNA Pseudouridylation (Pages: 69-107)

Pedro Morais,  Yi-Tao Yu

Self-Replicating RNA Viruses for Vaccine Development (Pages: 109-160)

Kenneth Lundstrom

Circular RNA Therapeutics and Vaccines (Pages: 161-176)

Xiang Liu,  Guizhi Zhu

Good Manufacturing Practices and Upscaling of mRNA Vaccine Production (Pages: 177-200)

Eleni Stamoula,  Theofanis Vavilis,  Ioannis Dardalas,  Georgios Papazisis

mRNA Vaccination for Induction of Immune Tolerance Against Autoimmune Disease (Pages: 201-240)
Mark C. Gissler,  Felix S.R. Picard,  Timoteo Marchini,  Holger Winkels,  Dennis Wolf

Part II : Recent Progress in Vaccine Research and Development

Design and Development of mRNA Vaccines to Combat the COVID -19 Pandemic (Pages: 241-258)

Istvan Tombacz

mRNA Vaccines for HIV-1 (Pages: 259-283)

Paolo Lusso

mRNA Vaccines Against Tick-borne Diseases (Pages: 285-301)
Gunjan Arora,  Erol Fikrig

mRNA Vaccines for Malaria and Other Parasitic Pathogens (Pages: 303-323)

Leroy Versteeg,  Jeroen Pollet

Current State of mRNA Vaccine Development Against Mycobacterium tuberculosis (Pages: 325-335)
Ilke Aernout,  Rein Verbeke,  Stefaan C. De Smedt,  Francis Impens,  Ine Lentacker

Cancer Vaccines Based on mRNA: Hype or Hope? (Pages: 337-400)
Wout de Mey,  Dorien Autaers,  Giada Bertazzon,  Arthur Esprit,  Marta Marco Aragon,  Lorenzo Franceschini,  Karine Breckpot

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