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Abstract
Several yield-related traits selected during crop domestication and improvement are associated with increases in meristem size, which is controlled by CLE peptide signals in the CLAVATA–WUSCHEL pathway. Here, we engineered quantitative variation for yield-related traits in maize by making weak promoter alleles of CLE genes, and a null allele of a newly identified partially redundant compensating CLE gene, using CRISPR–Cas9 genome editing. These strategies increased multiple maize grain-yield-related traits, supporting the enormous potential for genomic editing in crop enhancement.
摘 要
在作物驯化和改良过程中，有一些被选择的与产量相关的性状与分生组织的大小增加有关，而这些受到CLV-WUS途径中的CLE多肽信号调控。本文中，作者利用CRISPR-Cas9基因组编辑系统，通过制造CLE基因的弱启动子等位以及一个新鉴定的能够部分补偿CLE基因的无效等位基因，人工创制了产量相关性状的数量变异玉米种质。这些策略增加了多个与玉米产量相关的性状，彰显了基因组编辑技术在作物强化育种方面的巨大潜力。
冷泉港实验室David Jackson教授为本文通讯作者，Lei Liu博士为本文第一作者。该研究得到了美国国家科学基金（IOS-1546837）、Inari农业公司、韩国Next-Generation BioGreen 21 program（SSAC, PJ01322602）、中国博士后管委会办公室奖学金以及美国农业部NIFA博士后奖学金的联合资助。
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