Genes & Diseases 是以科研论文、综述、快讯等文章形式，报道生物医学交叉学科基础研究，以促进科技成果临床转化应用的生物医学综合性英文科技期刊。最新影响因子为6.9，在Biochemistry & Molecular Biology和Genetics & Heredity两个学科均位于Q1区！
2024年第5期已上线，欢迎阅览。
Rapid Communications
Rare dentin defects: Understanding the pathophysiological mechanisms of COLXVA1 mutations
Isaac Maximiliano Bugueno, Tristan Rey, Alexandra Jimenez-Armijo, Marzena Kawczynski, ... Virginie Haushalter-Laugel.
Proteomic analysis of urinary exosomes reveals ferroptosis-associated proteins are involved in diabetic nephropathy
Kaida Mu, Yanping Yang, Xiaofei An, Jie Zhu, ... Jinan Zhang.
MACF1 deficiency suppresses tooth mineralization through IGF1 mediated crosstalk between odontoblasts and ameloblasts
Wuxia Qiu, Xiao Lin, Shaoqing Yang, Zhihao Chen, ... Airong Qian.
Acyl-CoA thioesterase 7 is oncogenic in breast cancer by promoting oxidative phosphorylation via PGC1α
Xiangyu Sun, Qiang Zhang, Mozhi Wang, Litong Yao, ... Yingying Xu.
Clinical and genetic heterogeneity of adult polyglucosan body disease caused by GBE1 biallelic mutations in China
Yikun Chen, Yan Shi, Yuan Gao, Yan Hu, ... Jin He.
A novel copper metabolism-related signature model for predicting the prognosis, target drugs, and immunotherapy in stomach adenocarcinoma
Kai Zhuang, Siqi Tang, Haixin Feng, Jinying Zhang, ... Zunnan Huang.
SPNS1 ablation drives skeletal muscle atrophy by disrupting mitophagy, mitochondrial function, and apoptosis in mice
Xianzhong Zhang, Fengmin Zhang, Haofan Wu, Zhen Yu, Chengle Zhuang.
A new autophagy-related nomogram and mechanism in multiple myeloma
Hanying Huang, Yang Li, Ziang Zhu, Yang Liu, ... Lingling Shu.
Neurokinin-2 receptor antagonist SR48968 induced necroptosis of myeloid leukemia cells by calcium overload-driven reactive oxygen species accumulation
Zhibin Yan, Xiangyu Hong, Qihao Lin, Leijie Wang, ... Caiyun Fu.
MAL2 DNA methylation serves as a biomarker for the diagnosis and prognosis of glioma
Hao Luo, Xing Xiao, Weiliang Hou, Jing Cai, ... Liang Chen.
Exome sequencing identifies a likely causative variant in 53% of families with ciliopathy-related features on renal ultrasound after excluding NPHP1 deletions
Konstantin Deutsch, Verena Klämbt, Thomas M. Kitzler, Tilman Jobst-Schwan, ... Sophia Schneider.
USP45 acts as an oncogene to regulate the proliferation of esophageal cancer cells
Kai Li, Qian Wang, Hua Bian.
CXCL13 shapes tumor immune microenvironment in ovarian cancer with homologous recombination deficiency
Yue Ding, Zheng Ye, Bo Ding, Songwei Feng, ... Yang Shen.
Genome-wide DNA methylome analysis reveals a critical role of methylation-dysregulated lncRNAs in autophagy regulation in glioblastoma
Hongying Zhao, Ying Liu, Meiting Fei, Lin Bo, ... Li Wang.
Alterations in expression and localization of POMGNT1 in the APP/PS1 mouse model of Alzheimer's disease
Hanxiao Jiang, Yuxue Feng, Xia Hao, Guiqiong He, Xiaofeng Li.
Comprehensive identification and potential application of genetic alteration-driven enhancer RNAs for eRNA-targeted therapy in breast cancer
Hongying Zhao, Caiyu Zhang, Lin Bo, Lixia Wang, ... Li Wang.
Unique anti-angiogenic effects, pharmacological targets and therapeutic mechanisms of Chinese herbal medicines for endometriosis
Bo Liang, Rui Dong, Sze Wan Hung, Yiran Li, ... Chi Chiu Wang.
Prognosis prediction and immune microenvironment features of breast cancer indicated by a cuproptosis-associated long non-coding RNA signature
Siyi Liu, Juanchan Huang, Wei Zhao.
MPZL1 as an HGF/MET signaling amplifier promotes cell migration and invasion in glioblastoma
Haimin Song, Bowen Ni, Xuetao Peng, Weijuan Xu, ... Yawei Liu.
Dominant negative effect as a novel mechanism of SPAST gene mutation in a large family with hereditary spastic paraplegia
Ke Deng, Haibo Ruan, Feifei Yu, Zhenle Pei, ... Shuo Zhang.
Comprehensive analysis of mitochondrial dynamic-related genes on their functions and prognostic values for glioblastoma multiforme
Zhu Xie, Wei Hua, Hongyan Wang.
Integrative analysis of tumor stemness and immune microenvironment deciphers novel molecular subtypes in hepatocellular carcinoma
Zhiyi Wang, Shuang Chen, Dongxiao Li, Hui Xu, ... Xinwei Han.
EZH2 is a prognostic factor associated with tumor stemness and immune infiltration in skull base chordoma
Qian Liu, Mingxuan Li, Yujia Xiong, Yutao Shen, ... Jiwei Bai.
Efficacy of rapid antigen self-testing for SARS-CoV-2 screening: Real-world evidence from a prospective cohort study
Yaoyue Hu, Bin Peng, Jie Fan, Zhu Yang, ... Ailong Huang.
Promising prognostic value of ATP binding cassette transporters and their correlation with tumor-infiltrating immune cells in lung adenocarcinoma
Linzi Wei, Qian Yu, Xueying Yang.
Tumor immunological phenotype-derived gene classification predicts prognosis, treatment response, and drug candidates in ovarian cancer
Chengbin Guo, Yuqin Tang, Zhihai Liu, Chuanliang Chen, ... Yongqiang Zhang.
Traction force with extracellular matrix mediated by cytoskeleton influences metastasis through SLC8A1 induced Wnt-β-catenin pathway in endometrial cancer
Xingchen Li, Xin Xu, Jianliu Wang.
Depletion of anti-CD47mAb in plasma by genetically modified cells for pre-transfusion testing
Fei Wang, Wenting Wang, Xiaoshuang Wu, Zhixin Liu, ... Xingbin Hu.
Multi-omics analysis to identify CBR3-AS1-hsa-miR-145-5p-MAP3K5 pathway as a ferroptosis-related ceRNA network in benign prostatic hyperplasia
Liang Zhou, Youyou Li, Jiaren Li, Hanyu Yao, ... Long Wang.
Serum metabolic profiling implicates mTOR activation and insulin resistance in the development of pulmonary hypertension in a rat model of pressure overload-induced heart failure
Qi Zhou, Chao Tang, Xinke Xu, Junhao Hu, ... Xiaojing Wu.
Helicobacter pylori mediated niche environment aberrations promote the progression of gastric cancer
Teng Yan, Hang Sun, Yuhui Liao, Jiajian Zhou.
MMP-9 deficiency accelerates the progress of periodontitis
Chun-Yan Wan, Yixin Yin, Xiaoyan Li, Meng Meng Liu, ... Shuo Chen.
CD147 facilitates cisplatin resistance in ovarian cancer through FOXM1 degradation inhibition
Miao Wang, Lin Chen, Yu Wang, Tian Fan, ... Yu Li.
Review Articles
The regulatory role of m6A modification in the maintenance and differentiation of embryonic stem cells
Jin Zhang, Lingling Tong, Yuchen Liu, Xiang Li, ... Di Chen.
Exploiting the potential of the ubiquitin-proteasome system in overcoming tyrosine kinase inhibitor resistance in chronic myeloid leukemia
Xudong Li, Wei Li, Yanli Zhang, Linping Xu, Yongping Song.
Recent advancement of sonogenetics: A promising noninvasive cellular manipulation by ultrasound
Jin Tang, Mingxuan Feng, Dong Wang, Liang Zhang, Ke Yang.
LncRNAs are involved in regulating ageing and age-related disease through the adenosine monophosphate-activated protein kinase signalling pathway
Jiamei Li, Feng Xiao, Siqi Wang, Xiaolan Fan, ... Deying Yang.
Mechanism and application of feedback loops formed by mechanotransduction and histone modifications
Han Sun, Yafang Gao, Xinyu Ma, Yizhou Deng, ... Lisha Li.
Protein lysine crotonylation in cellular processions and disease associations
Hongling Zhao, Yang Han, Pingkun Zhou, Hua Guan, Shanshan Gao.
The landscape of epigenetic regulation and therapeutic application of N6-methyladenosine modifications in non-coding RNAs
Gui-e Xu, Xuan Zhao, Guoping Li, Priyanka Gokulnath, ... Junjie Xiao.
The molecular genetics of PI3K/PTEN/AKT/mTOR pathway in the malformations of cortical development
Qing Ma, Guang Chen, Ying Li, Zhenming Guo, Xue Zhang.
M6A modification in cardiovascular disease: With a focus on programmed cell death
Wen Li, Yao Liu, Ruiyan Xu, Yuan Zong, ... Guohua Li.
Homeostatic regulation of NAD(H) and NADP(H) in cells
Luojun Chen, Xiaoke Xing, Pingfeng Zhang, Lulu Chen, Huadong Pei.
Epigenetics: Mechanisms, potential roles, and therapeutic strategies in cancer progression
Dong Wang, Yan Zhang, Qingbo Li, Yu Li, ... Shuhua Lyu.
Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies
Jiankun Fan, Zhigang Li, Li Pei, Yu Hou.
Vitamin D binding protein in psychiatric and neurological disorders: Implications for diagnosis and treatment
Ling Li, Bing Han, Yan Kong, Gaojia Zhang, Zhijun Zhang.
Full Length Articles
Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium
Jinxuan Zheng, Rongcheng Yu, Yiqi Tang, Sihui Su, ... Yang Cao.
XBP1 splicing contributes to endoplasmic reticulum stress-induced human islet amyloid polypeptide up-regulation
Yun Zhang, Susan Lin, Jing Yao, Wantong Cai, ... Weihong Song.
Profibrotic role of the SOX9–MMP10–ECM biosynthesis axis in the tracheal fibrosis after injury and repair
Lei Gu, Anmao Li, Chunyan He, Rui Xiao, ... Shuliang Guo.
Multi-omics integration reveals potential stage-specific druggable targets in T-cell acute lymphoblastic leukemia
Zijun Yan, Jie Xia, Ziyang Cao, Hongyang Zhang, ... Lin Zou.
PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype
Fengsheng Dai, Yixiao Yuan, Jiaqi Hao, Xing Cheng, ... Tingxiu Xiang.
Integrative analysis of the transcriptome and metabolome reveals the importance of hepatokine FGF21 in liver aging
Wenchao Wang, Junjie Qian, Mingge Shang, Yiting Qiao, ... Shusen Zheng.
Narciclasine induces colon carcinoma cell apoptosis by inhibiting the IL-17A/Act1/TRAF6/NF-κB signaling pathway
Huiming Deng, Qiang Liu, Siman Yu, Lifan Zhong, ... Ronghua Xu.
Coupled single-cell and bulk RNA-seq analysis reveals the engulfment role of endothelial cells in atherosclerosis
Jianxiong Xu, Jinxuan Wang, Hongping Zhang, Yidan Chen, ... Guixue Wang.
Down-regulation of microRNA-23a promotes pancreatic ductal adenocarcinoma initiation and progression by up-regulation of FOXM1 expression
Lixin Liang, Tian Cai, Xiaojia Li, Jianhong An, ... Tingting Jiang.
Inhibiting HMGCR represses stemness and metastasis of hepatocellular carcinoma via Hedgehog signaling
Zhirong Zhang, Jiayao Yang, Rui Liu, Jing Ma, ... Ni Tang.
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