开创性发现通常是在阅读了高质量同行评审期刊发表的多种研究之后的。
为帮助生物技术领域的读者紧跟行业最新态势，ACS出版社精心整理了13篇2024年以来引起生物技术公司极大兴趣的优秀期刊论文，以及在发表后不久就被专利援引的颇具影响力的论文。
文末还展示了在ACS数据库查询施引专利的方法哦！
1
2024年以来生物技术公司访问最多的文章
Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor
DOI: 10.1021/jacs.3c03886
发表于：Journal of the American Chemical Society 2023
访问量：2.2万
Transition-Metal-Free C–N Cross-Coupling Enabled by a Multifunctional Reagent
DOI: 10.1021/jacs.4c00871
发表于：Journal of the American Chemical Society 2024
访问量：2.6万
Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets
DOI: 10.1021/jacs.3c07145
发表于：Journal of the American Chemical Society 2023
访问量：1.7万
Synthetic Approaches to the New Drugs Approved During 2022
DOI: 10.1021/acs.jmedchem.3c02374
发表于：Journal of Medicinal Chemistry 2024
访问量：1万
Emerging and Re-emerging Warheads for Targeted Covalent Inhibitors: An Update
DOI: 10.1021/acs.jmedchem.3c01825
发表于：Journal of Medicinal Chemistry 2024
访问量：1.3万
Beyond Rule of Five and PROTACs in Modern Drug Discovery: Polarity Reducers, Chameleonicity, and the Evolving Physicochemical Landscape
DOI: 10.1021/acs.jmedchem.3c02332
发表于：Journal of Medicinal Chemistry 2024
访问量：7000+
Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton’s Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies
DOI: 10.1021/acs.jmedchem.3c01007
发表于：Journal of Medicinal Chemistry 2024
访问量：1.6万
Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors
DOI: 10.1021/acs.jmedchem.3c02098
发表于：Journal of Medicinal Chemistry 2024
访问量：6000+
MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery
DOI: 10.1021/acs.jmedchem.3c02029
发表于：Journal of Medicinal Chemistry 2024
访问量：4000+
Balanced Permeability Index: A Multiparameter Index for Improved In Vitro Permeability
DOI: 10.1021/acsmedchemlett.3c00542
发表于：ACS Medicinal Chemistry Letters 2024
访问量：5000+
NMR Chemical Shifts of Trace Impurities: Industrially Preferred Solvents Used in Process and Green Chemistry (OA)
DOI: 10.1021/acs.oprd.5b00417
发表于：Organic Process Research & Development 2016
访问量：57万
Late-Stage Saturation of Drug Molecules (OA)
DOI: 10.1021/jacs.4c00807
发表于：Journal of the American Chemical Society 2024
访问量：2.6万
Formation of N-Nitrosamine Drug Substance Related Impurities in Medicines: A Regulatory Perspective on Risk Factors and Mitigation Strategies (OA)
DOI: 10.1021/acs.oprd.3c00153
发表于：Organic Process Research & Development 2023
访问量：4.3万
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专利引用过的新近文章
TCFH–NMI: Direct Access to N-Acyl Imidazoliums for Challenging Amide Bond Formations (OA)
DOI: 10.1021/acs.orglett.8b01591
施引专利：7个
Amide Bond Bioisosteres: Strategies, Synthesis, and Successes
DOI: 10.1021/acs.jmedchem.0c00530
施引专利：9个
An Organic Chemist’s Guide to N-Nitrosamines: Their Structure, Reactivity, and Role as Contaminants (OA)
DOI: 10.1021/acs.joc.0c02774
施引专利：1个
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα
DOI: 10.1021/acs.jmedchem.2c01422
施引专利：1个
Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design
DOI: 10.1021/acs.jmedchem.1c01215
施引专利：3个
TIPS：施引专利的查询方法
进入网页版全文，在右上角找到“三个数字”，分别是文章被访问量、综合被引指数Almetrics、以及被学术论文引用的次数：
将鼠标悬停于Almetrics数据，可以看到文章被研究人员社交账号推荐或被专利引用的次数；点击后可查看明细。
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