Some factors affecting drug absorption are the rate of dissolution. Drugs that dissolve faster are absorbed faster. 影响药物吸收的因素包括溶出速度。溶解较快的药物吸收更快。
Surface area, since the lining of the small intestine has more surface area than the lining of the stomach, most drugs are absorbed faster in the small intestine. 表面积,由于小肠黏膜的表面积比胃黏膜大,因此大多数药物在小肠内吸收得更快。
Blood flow, the greater the concentration gradient between the drug-filled stomach and the rapidly flowing drug-free blood, the faster the absorption. 血流量,充满药物的胃与快速流动的无药物血液之间的浓度梯度越大,吸收速度越快!
Lipid solubility, highly lipid soluble drugs pass through the phospholipids in the cell membrane more easily than drugs of low lipid solubility. 脂溶度,高脂溶性药物比低脂溶性药物更容易通过细胞膜磷脂。
And PH partitioning, absorption is faster when the difference between the PH at the site of administration and the PH of the plasma attracts more drug molecules to ionize in the plasma. PH-分配,当给药部位的 PH 与血浆 PH 之间的差异吸引更多药物分子在血浆中电离时,药物吸收更快!
Bioavailability
Enteric
Phospholipid
精品好课推荐