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今天给大家讲的是阿尔茨海默病（Alzheimer’s disease,
AD）临床前期主观认知下降（Subjective Cognitive
Decline, SCD）向轻度认知障碍（Mild Cognitive Impairment, MCI）或AD痴呆的转化风险。
首先，AD临床前期SCD作为AD临床前期的最早期阶段，有很高的向MCI或AD痴呆转化的风险。
同时Mitchell等报道记忆诊所或专科的Meta分析显示，在超过3.3年的随访中，SCD向MCI的转化率为16.48%，年转化率为5.6%。超过3.2年的随访中，痴呆的转化率为11.7%，年转化率为3.2%。研究显示，SCD向痴呆的年转化为2.9%-11%。
参考文献：
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[10] Edwards E R, Lindquist K, Yaffe K. Clinical profile and course of cognitively normal patients evaluated in memory disorders clinics[J]. Neurology, 2004,62(9):1639-1642.
[11] van der Flier W M, van der Vlies A E, Weverling-Rijnsburger A W, et al. MRI measures and progression of cognitive decline in nondemented elderly attending a memory clinic[J]. Int J Geriatr Psychiatry, 2005,20(11):1060-1066.
图文编辑：郝立晓博士
