课题组长介绍
叶菱秀研究员，上海交通大学思源学者、上海交通大学医学院上海市免疫学研究所资深研究员、附属瑞金医院免疫与疾病研究中心双聘研究员，国家自然科学基金优青项目获得者。叶菱秀研究员于2010年获得剑桥大学博士学位，2010年至2015年在哈佛大学医学院从事博士后研究工作，2016年2月加入上海市免疫学研究所，任“抗体分子免疫学”课题组组长。
叶菱秀课题组长期致力于B淋巴细胞抗体多样化分子机制研究，特别是广谱中和抗体产生中DNA损伤修复研究。在体液免疫反应和中和抗体发现方向上积累了各种技术系统和完善的研究体系，并取得了多项原创成果。实验室依托上海市免疫学研究所一流科研平台和交大医学院丰富的临床资源，聚焦抗病毒广谱高效中和抗体产生机制研究和自身免疫抗体产生及自身免疫疾病发生的机制研究，已与交大医学院附属瑞金医院开展深度合作并设立了联合培养博士后项目。合作的博士后获的教育部博士后创新人才支持计划，上海市“超级博士后”激励计划，上海市免疫学研究所余㵑博士后。近2年代表性通讯作者论文包括Cell（2023）、Science Immunology（2023）、Nature Cell Biology（2024）、Trends in Immunology（2024）。
2、如有抗体筛选相关经验，则优先考虑。
2、能熟练运用相关计算机语言编写满足研究需求的新程序；
3、如有单细胞测序、ATAC-seq和RNA-seq等相关数据分析经验，则优先考虑；
4、如在短期内拟继续攻读博士学位或从事博士后研究，也诚邀加入。
研究方向：
1、神经、免疫发育过程中的DNA损伤修复机制；
2、自身免疫抗体产生及自身免疫疾病发生的机制 （与瑞金医院内分泌科合作）；
3、利用AI技术寻找生物进化中抗体基因特征。
博士后要求：
1、具有分子生物学、细胞生物学、免疫学、神经生物学或生物信息学等相关专业博士学位；
2、具有科学态度严谨，思维活跃，有好奇心；具备较强的工作责任心和团队协作精神；
3、提供具有竞争力的待遇，优秀博士后可入选“上海市免疫学研究所博士后创新计划”和“上海市免疫学研究所余㵑博士后”，也可申请上海交通大学医学院附属瑞金医院-上海市免疫学研究所“免疫与疾病研究中心”博士后。
有意者请将个人简历及其认为重要的相关材料以电子邮件形式发送至：yeaplengsiew@shsmu.edu.cn ，应聘材料将予以严格保密。经审核合格的候选者我们将会邮件通知面试的具体时间、地点及其他相关事项。实验室网页请访问上海市免疫学研究所官方网站：https://www.shsmu.edu.cn/sii/info/1053/1455.htm
JOIN US
Three Postdoctoral Research Fellow and two technician positions are available in the laboratory of Dr. Leng Siew Yeap at Shanghai Institute of Immunology (SII), Shanghai Jiaotong University School of Medicine. Dr. Yeap received her Ph.D. from University of Cambridge in 2010 and completed her postdoctoral training in the laboratory of Dr. Frederick Alt at Harvard Medical School. In 2016, she joined Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine as a Principal Investigator. She is currently a Senior Investigator at SII and a Siyuan Scholar of Shanghai Jiao Tong University. The Yeap lab focuses on understanding the mechanisms that generate rare mutagenic outcomes during antibody diversification processes and how these mutations contribute to antiviral broadly neutralizing activities or autoimmune diseases. Recent publication from the lab includes Cell (2023), Science Immunology (2023), Nature Cell Biology (2024), and Trends in Immunology (2024).
Research Interests
1. Mechanisms of DNA damage and repair during neuronal and immune cell development;
2. Mechanisms of autoimmune diseases (collaboration with Ruijin Hospital);
3. Discovering new features of antibody genes during evolution using AI technology.
Job Requirements
Postdoctoral fellows (3 positions available)
1. The applicants have a Ph.D. degree in the field of molecular biology, cell biology, immunology, neurobiology, bioinformatics or related fields and are interested in leading one of the three research projects listed above.
2. The applicants are expected to have passion for research, critical thinking, and team spirit.
3. Successful applicants will be provided with a competitive salary. Outstanding candidates will be enrolled in the SII Postdoctoral Incentive Plan, or Yu He Postdoctoral Fellowship. In addition, they can also apply for the joint postdoctoral program between SII and Ruijin Hospital.
Technician – antibody screening (1 position)
1. The applicants have a Master degree in the field of molecular biology or immunology.
2. Candidates with antibody screening experience will be preferred although not necessary.
Technician – bioinformatics (1 position)
1. The applicants have a Master or a Ph.D. degree in computer science, bioinformatics, or relevant subjects and are interested to work together with biologists in the laboratory.
2. The candidates are expected to be proficient in computer language and writing scripts.
3. Candidates with experience in genomic analysis such as single-cell ATAC-seq and RNA-seq are preferred.
4. Candidates who are in their gap year and planning to further their studies in the future are encouraged to apply for a short term work.
Interested applicants can send their curriculum vitae to Dr. Yeap at yeaplengsiew@shsmu.edu.cn .
More information about the lab can be found at the SII website https://www.shsmu.edu.cn/sii/info/1166/2476.htm
