The Secret in the Tumor Cell
Introduction
Although cancer is generally considered to be a disease caused by genetics and environmental factors, microorganisms are implicated in about 20% of human malignancies. With advancements in high-throughput sequencing and immunology, research on the relationship between microbes and cancer has revived in recent decades. In the introduction, we will describe the research background and make a brief discussion.
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science. 2018 Jan 5;359(6371):97-103. doi: 10.1126/science.aan4236. Epub 2017 Nov 2. PMID: 29097493; PMCID: PMC5827966.
Main Paper I
Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite. Cancer Cell. 2024 Jun 10;42(6):985-1002.e18. doi: 10.1016/j.ccell.2024.05.006. Epub 2024 May 30. PMID: 38821061.
Pre-clinical mouse models suggest that the gut microbiome modulates tumor response to checkpoint blockade immunotherapy; however, this has not been well-characterized in human cancer patients. This research examined the oral and gut microbiome of melanoma patients undergoing anti-PD-1 immunotherapy trying to figure out the correlation between the microbiome and checkpoint blockade therapy.
Main Paper II
Li et al. reveal that tumor cells mimic the anti-inflammatory mechanism of central nervous system to evade anti-tumor immunity by expressing brain-enriched N-acetyltransferase 8-like (NAT8L) and its metabolite N-acetylaspartate (NAA). NAA impairs the formation of immunological synapse by cytotoxic immune cells. NAT8L is a potential target for cancer immunotherapy.
Cancer and the microbiota. Science. 2015 Apr 3;348(6230):80-6. doi: 10.1126/science.aaa4972. PMID: 25838377; PMCID: PMC5535753.
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JC 基本信息
/ INFORMATIONS
时间
2024年12月28日14：00-17：00
地点
北京大学吕志和楼B101
主讲人
张昊宁 王天祺 曾静璇
嘉宾
胡婧（北京大学）
班主任
Jackson Champer
欢迎感兴趣的同学给主讲人发邮件报名旁听本次JC：
张昊宁2100012111@stu.pku.edu.cn
王天祺2200012129@stu.pku.edu.cn
曾静璇2210307227@stu.pku.edu.cn
本次JC提供晚餐，如有忌口请在邮件中一并告知。
References
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science. 2018 Jan 5;359(6371):97-103. doi: 10.1126/science.aan4236. Epub 2017 Nov 2. PMID: 29097493; PMCID: PMC5827966.
Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite. Cancer Cell. 2024 Jun 10;42(6):985-1002.e18. doi: 10.1016/j.ccell.2024.05.006. Epub 2024 May 30. PMID: 38821061.
Cancer and the microbiota. Science. 2015 Apr 3;348(6230):80-6. doi: 10.1126/science.aaa4972. PMID: 25838377; PMCID: PMC5535753.
供稿｜张昊宁 王天祺 曾静璇
排版｜张静函
审核｜赵文迪
