IL-36分子及信号通路
IL-36信号通路(文献2)
IL-36作用靶细胞及功能
IL-36作用靶细胞及功能(文献3)
成纤维细胞:激活,分泌GM-CSF,IL-6,产生胶原蛋白
T细胞:IL-36R主要表达于CD4+T细胞,促进向Th1,Th17分化,并促进其增殖,炎症细胞因子产生
IL-36促进巨噬细胞,DC细胞,上皮细胞,角质细胞活化,分泌炎症因子IL-6,IL-1β,IL-12,IL-23,TNF-α等。
IL-36与疾病
1. 炎症性疾病
2. 抗感染
IL-36药物开发
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