本Meta分析遵循PRISMA指南（注册号CRD42020148258），以“screening and hepatocellular carcinoma”为关键词，检索了至2021年6月30日的PubMed、Embase、Cochrane图书馆等数据库及中文数据库中的文献，并查阅综述文章的参考文献以发现更多研究。 两位研究者独立筛选文献，通过讨论解决分歧。纳入标准为：①研究对象为HCC高危人群；②比较了HCC筛查的间隔或方法；③报告了治疗效果和/或不良事件；④为比较性研究（RCT或队列研究）。排除重复、数据缺失或无法获取的研究，以及比较筛查与非筛查的研究。若研究多次报道，选择信息量最大或随访时间最长的研究。
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