Tailoring lipid nanoparticle dimensions through manufacturing processes
Caitlin McMillan, Amy Druschitz, Stephen Rumbelow, Ankita Borah, Burcu Binici, Zahra Rattray and Yvonne Perrie* (思克莱德大学, 英国)
👉 LNP particle size control can be achieved through manufacturing processes. Changes in particle size affect in vitro efficacy but not in vivo potency. Created with BioRender.com.
Dextrin conjugation to colistin inhibits its toxicity, cellular uptake and acute kidney injury in vivo
Mathieu Varache, Siân Rizzo, Edward J. Sayers, Lucy Newbury, Anna Mason, Chia-Te Liao, Emilie Chiron, Nathan Bourdiec, Adam Jones, Donald J. Fraser, Philip R. Taylor, Arwyn T. Jones, David W. Thomas and Elaine L. Ferguson*(卡迪夫大学，英国)
👉 The acute kidney injury (AKI) and dose-limiting nephrotoxicity, which occurs in 20–60% of patients following systemic administration of colistin, represents a challenge in the effective treatment of multi-drug resistant Gram-negative infections.
Structure–activity relationships of DNA nanocarriers based on the amphipathic cell penetrating peptide transportan 10
Lucas Rodrigues de Mello, Tâmisa Seeko Bandeira Honda, Sang Won Han, Valeria Castelletto, Ian William Hamley, Ly Porosk, Ülo Langel and Emerson Rodrigo da Silva* (圣保罗大学，巴西)
👉 Cell penetrating peptides (CPPs) have emerged as promising materials for the fabrication of synthetic nanovectors endowed with potential for improving the future landscape of gene therapy.
👉 Multilamellar wall nanocarriers made of poly-L-lysine and microbial single glucose lipids can be loaded with lipophilic drugs. This system can be used as a drug carrier for preferential drug delivery to HeLa cells.
Cancer immunotherapy boosted by layered double hydroxide nanoparticles
Xiaochun Deng, Gaoming Li, Mingwu Shen*（东华大学，沈明武） and Xiangyang Shi*（东华大学，史向阳）
👉 Recent advances and some key developments in the construction of layered double hydroxide-based nanoplatforms or vaccines for cancer immunotherapy have been reviewed.
