Food-borne pathogens and the pig industry
Salmonella enterica is a pathogen that can cause serious food-borne illnesses in humans. As many cases go unreported, the prevalence of infections might be largely underestimated, underscoring the importance of understanding the reasons for the rise of S. enterica. Human activities contribute to the global spread of this pathogen, much of which comes from modernized livestock production systems. Over the past century, the pig industry has contributed to the spread of S. enterica through intensive farming, overuse of antimicrobials leading to the acquisition of resistance genes, and the global pork trade. Pigs are now the main source of transmission of the pathogen to other hosts. Greater emphasis on the surveillance of S. enterica infections in humans and animals is key to prevent future disease outbreaks.
PJ:扬州大学报道一个参与植物抗旱的WRKY转录因子
本研究从基因表达入手，发现了一个Paeonia ostii中受到干旱调控的= WRKY transcription factor-PoWRKY69, 该转录因子是植物耐受干旱胁迫的正调控子。
PoWRKY69 可以直接结合到fructose-1,6-bisphosphate aldolase 5 (PoFBA5) 的 W-box上诱导它的表达。通过转基因及基因沉默的分析证实 PoFBA5通过维持果糖水平来降低膜脂的过氧化并激活抗氧化系统。
在蛋白水平上valine-glutamine 11 (PoVQ11) 与PoWRKY69互作从而提高PoWRKY69对PoFBA5的表达调控能力。
小结：本研究揭示了WRKY69介导的植物耐旱机制。
原文：PoWRKY69-PoVQ11 module positively regulates drought tolerance by accumulating fructose in Paeonia ostii
