Title: CsTL CONTROLS TENDRIL FORMATION IN CUCUMBER. On the cover: Cucumber CsTL has a divergent function compared with its Arabidopsis homolog, promoting tendril formation by acting as a cofactor with CsTEN to directly induce CsUFO. See Shen et al on pg 2818. Image credit: Zheng Li.
新植物学家：浙江大学揭示独角金内酯介导的冷胁迫响应机制
细胞自噬在植物响应逆境胁迫条件下发挥重要作用。本研究解析了独角金内酯在冷胁迫条件下通过调控细胞自噬来影响植物冷胁迫耐受性的机制。研究显示独角金内酯的合成突变体对冷胁迫的敏感度显著变高，同时植物体内被泛素化的蛋白水平也显著提高。利用合成的独角金内酯的类似物GR245DS处理可以提高番茄对冷胁迫的耐受性，这与自噬小体的增加有关，同时发现 autophagy-related genes (ATGs)的表达被诱导, 泛素化的蛋白水平显著下降. 基因表达分析显示冷胁迫可以通过独角金内酯来诱导ELONGATED HYPOCOTYL 5 (HY5)的表达, 它诱导了 ATG18a的转录，从而促进了细胞自噬过程。突变ATG18a抑制了独角金内酯介导的对冷胁迫的耐受性，同时抑制了自噬小体的形成和提高了泛素化蛋白的水平。
小结：本研究揭示了独角金内酯介导的提高植物冷胁迫耐受性的机制。
Proposed model showing strigolactone-induced cold tolerance by activation of autophagy in an HYPOCOTYL 5 (HY5)-dependent manner in tomato. Cold stress induces strigolactone biosynthesis in tomato, further increasing the abundance of HY5, which trans-activates ATG18a expression, thereby triggering enhanced autophagy to degrade cold-induced denatured and unfolded proteins. Arrows indicate positive regulation. Solid arrows indicate direct promotion. The dashed arrow represents a potential boost.
原文：Strigolactones positively regulate HY5-dependent autophagy and the degradation of ubiquitinated proteins in response to cold stress in tomato
