Cover image: Pictured is an artistic illustration of a folded protein on a computer chip. A collection of articles in the From Basic Mechanisms and Cellular Machineries to AI Solutions in Protein Folding Special Feature highlights recent advances in the use of deep learning models and AI algorithms to understand and predict protein structures and folding patterns. Together, the articles explore the physico-chemical rules that govern protein folding, the biological machinery of protein quality control, and the origins of neurodegenerative pathologies associated with protein misfolding. See the Introduction to the Special Feature, e2411135121. Image credit: Art by Sarina Bromberg (Three Arrows Cooperative Society, Putnam Valley, NY), with concept by Charles D. Kocher and Ken A. Dill (Stony Brook University, Stony Brook, NY).
MP:安徽农业大学揭示ABA和JA协同修复植物损伤的分子机制
植物利用两种不同的机制应对损伤：修复和再生。本研究发现由不同损伤模式导致的局部生长素累积模式可以激活不同的修复机制。首先，茉莉酸信号可以在损伤发生后几个小时内促进木质素的合成。
然后，茉莉酸信号途径中的转录因子MYC2会随之激活ABA信号转导过程。JA信号转导会促进ABA的合成来维持一个木质素合成相关转录因子 RAP2.6的持续性表达从而维持木质素合成以及最后的损伤修复过程。
小结：本研究揭示了JA和ABA两条信号途径在植物损伤修复过程中的作用机制。
原文：Xu H., Dong C., Wu Y., Fu S., Tauqeer A., Gu X., Li Q., Niu X., Liu P., Zhang X., Li C., Li M., and Wu S. (2024). The JA-to-ABA signaling relay promotes lignin deposition for wound healing in Arabidopsis. Mol. Plant. 17, 1594–1605.
