BioArt人才
华盛顿大学炎症性肠病实验室
教授简介
学校简介:
圣路易斯华盛顿大学医学院(Washington University School of Medicine in St. Louis)是美国最顶尖的医学研究机构之一。常年在《美国新闻与世界报道》(US News & World Report)最佳医学院中名列前十。至今已产生19位诺贝尔奖获得者,在世界范围内享有盛名。2023年,华盛顿大学医学院从美国国立卫生研究院 (NIH) 获得的资助金额在所有医学院中位居第二。
首席研究员(PI)简介
曹思雁教授本科毕业于浙江大学竺可桢学院。2013年于密歇根大学(University of Michigan, Ann Arbor)获得生物化学博士学位(PhD),2016年于哥伦比亚大学(Columbia University)获得医学博士学位(MD)。并在加州大学旧金山分校(UCSF)完成内科住院医师训练。后在华盛顿大学进行胃肠病学专科训练以及博士后研究,师从美国国家科学院院士Marco Colonna教授。现为华盛顿大学胃肠病学系助理教授、主治医师、炎症性肠病(IBD)与肠道免疫实验室首席研究员(PI)。从事IBD相关的基础及转化研究,以第一作者或通讯作者在Gastroenterology, J. Clin. Invest., PNAS, J. Crohn’s Colitis等国际著名期刊上发表论文17篇 https://www.ncbi.nlm.nih.gov/myncbi/siyan.cao.1/bibliography/public/。担任Nat. Metab., PNAS, J. Crohn’s Colitis, Cell. Mol. Gastroenterol. Hepatol., Inflamm. Bowel Dis., Am. J. Physiol.等期刊以及 Crohn’s and Colitis UK, Digestive Disease Week等机构和会议的独立审稿人。实验室得到NIH/NIDDK, Crohn’s and Colitis Foundation, American Gastroenterological Association, Doris Duke Foundation等机构的资助。
https://gastro.wustl.edu/people/siyan-stewart-cao-md-phd/
https://gastro.wustl.edu/research/
招聘岗位
IBD与肠道免疫实验室及职位概要
实验室利用分子和细胞生物学、多组学技术(包括单细胞和空间转录组学、蛋白质组学、全基因组/外显子组测序、宏基因组学)、小鼠模型和人体组织样本来研究IBD中与疾病相关的细胞和器官信号通路。主要研究项目包括1)先天淋巴细胞(innate lymphoid cells)在小鼠IBD模型中的功能与调控;2)肠道纤维化和肛周瘘管克罗恩病的免疫学机制;3) IBD相关并发症的多组学分析;4) IBD 诊断和疗法的生物标志物发现。
实验室诚聘积极主动,富有创造力,独立且热情的博士后学者来进一步推进对IBD的基础和转化研究。研究项目提供了高度协作和支持性的培训环境,以发展和培养独立的职业生涯。成功的候选人将有机会使用新型小鼠模型和尖端的多组学方法来了解与IBD直接相关的分子机制。职责包括实验设计、执行、数据分析和手稿准备,并有很多机会在国际重要会议上发表演讲和学术交流。
所需资格
PhD, MD或同等学位,具有实验室研究经验。
优先资格
- 在重要期刊上发表第一作者论文的候选人;
- 有处理胃肠道疾病和/或免疫学小鼠模型的经验;
- 基础分子、细胞生物学和免疫学技术的专业知识,包括细胞培养、流式细胞术、核酸分离、PCR、蛋白质印迹、ELISA、免疫组织化学/免疫荧光和显微镜检查;
- 基本的统计和计算知识;
- 优秀的口头沟通和书面表达能力,具有良好的组织和分析能力。
简历投递
欢迎感兴趣的同学直接联系曹教授,请提供简历(包括论文、研究项目、推荐人信息)和入职时间。
Postdoctoral Research Associate - Job Description
Position Summary
Postdoctoral positions are available in the Cao Laboratory within the Division of Gastroenterology, Department of Medicine at the Washington University School of Medicine in St. Louis, USA. We seek highly motivated, creative, independent, and enthusiastic scientists to further our basic and translational studies of inflammatory bowel disease (IBD).
We study disease-relevant cell and organ signaling pathways in IBD (including Crohn’s disease and ulcerative colitis) using molecular and cell biology, multi-omics technologies (e.g., single-cell and spatial transcriptomics, proteomics, whole-genome/exome sequencing, metagenomics), murine models, and human tissues. We currently have four major focuses: 1) Innate lymphoid cells (ILC) in murine IBD; 2) Innate immune mechanisms in perianal and fibrostenotic Crohn’s disease; 3) Multi-omics analyses of IBD-related complications, including Crohn’s of the pouch, perianal Crohn’s disease, and upper GI Crohn’s disease, and extraintestinal manifestations of IBD; 4) Biomarker discovery for IBD therapies (e.g., anti-IL-23s and JAK inhibitors) and diagnosis (e.g., fibrostenotic Crohn’s disease). https://www.ncbi.nlm.nih.gov/myncbi/siyan.cao.2/bibliography/public/
Our research program provides a highly collaborative and supportive training environment to develop and foster independent careers. Successful candidates will have the opportunity to use novel mouse models and cutting-edge techniques to understand molecular mechanisms with direct relevance to human disease. Responsibilities will include experimental design, execution, data analysis, and manuscript preparation, with ample opportunities for presentations at national and international scientific meetings.
Required Qualifications
Ph.D., M.D. or equivalent terminal or doctoral degree with experience in bench research.
Preferred Qualifications
A track record of scientific productivity is essential, preference will be given to candidates with first-author publications in high-impact journals.
Prior experience in working with mouse models of GI disease and/or immunology is highly desirable.
Expertise in basic molecular, cell biology, and immunology techniques including cell culture, flow cytometry, nucleic acid isolation, PCR, molecular cloning, Western blot, ELISA, immunohistochemistry/immunofluorescence, and microscopy.
Basic statistical and computational knowledge.
Excellent oral communication and written skills, with good organizational and analytical abilities.
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