温故而知新专栏｜病毒系列（6）：支持细胞和整个系统的功能医学策略

• To evaluate the metabolic and immune effects of dietary arginine,glutamine and omega-3 fatty acids (fish oil) supplementation, we performed a prospective study.

  CONCLUSIONS: The feeding of Neomune in critically injured patients was well tolerated as Traumacal and significant improvement was observed in serum protein.Shorten ICU stay and wean-ofrespirator day may beneft from using the immunonutrient formula."Chuntrasakul et al.Comparison of a immunonutrition formula enriched arginine,glutamine and omega-3 fatty acid， with a currently high-enriched enteral nutrition for trauma patients. J/ Med Assøc Thai.2003 Jun;86（6）∶552-6

•  CONCLUSIONS:In conclusion, arginine-enhanced formula improves fistula rates in postoperative head and neck cancer patients and decreases length of stay."de Luis et al. Randomized clinical rial with an enteral arginine-enhanced formula in early postsurgical head and neck cancer patients.Eur./ Clin Nur.2004;58(11):1505-8
•  "In this prospective,randomised, double-blind,placebo-controlled study, we randomly assigned 50 patients who were scheduled to undergo coronary artery bypass to receive either an oral immune-enhancing nutritional supplement containing L-arginine,omega3 polyunsaturated fatty acids,and yeast RNA(n=25),or a control (n=25) for a minimum of 5 days..Intake of an oralimmune-enhancing nutritional supplement for a minimum of 5 days before surgery can improve outlook in high-risk patients who are undergoing elective cardiac surgery." Tepaske et al. Effect of preoperative oral immune-enhancing nutritional supplement on patients at high risk of infection after cardiac surgery: a randomised placebo-controlled trial. Lancet.2001 Sep 1;358(9283):696-701
• "The feeding of IMMUNE FORMULA was well tolerated and significant improvement was observed in nutritional and immunologic parameters as in other immunoenhancing diets. Further clinical trials of prospective double-blind randomized design are necessary to address the so that the necessity of using immunonutrition in critically ill patients will be clarified."Chuntrasakul et al. Metabolic and immune effects of dietary arginine,glutamine and omega-3 fatty acids supplementation in immunocompromised patients.J Med Assoc Thai. 1998 May;81(5):334-43
• "enteral diet supplemented with arginine, dietary nucleotides,and omega-3 fatty acids (IMPACT,Sandoz Nutrition, Bern, Switzerland)" Senkal et al. Early postoperative enteral immunonutrition: clinical outcome and cost-comparison analysis in surgical patients. Cri Care Med 1997;25(9):1489-96
• "..supplemented diet with glutamine, arginine and omega-3-fatty acids...It was clearly established in this trial that early postoperative enteral feeding is safe in patients who have undergone major operations for gastrointestinal cancer. Supplementation of enteral nutrition with glutamine. arginine, and omega-3-fatty acids positively modulated postsurgical immunosuppressive and inflammatory responses."Wu et al.Modulation of postoperative immune and inflammatory response by immune-enhancing enteral diet in gastrointestinal cancer patients. World J Gastroenterol.2001 Jun;7(3):357-62 wignet.com/1007-9327/7/357.pdf
• "using a formula supplemented with arginine, mRNA, and omega-3 fatty acids from ish oil Impact)..CONCLUSIONS: Immune-enhancing enteral nutrition resulted in a significant reduction in the mortality rate and infection rate in septic patients admitted to the ICU. These reductions were greater for patients with less severe illness."Galban et al. An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients. Crit Care Med.2000 Mar;28(3):643-8
• Curtis et al.Understanding the Mediterranean diet. Could this be the new"gold standard" for heart disease prevention? Postgrad Med.2002 Aug;112(2):35-8,41-5
• Knoopset a. Mediterranean diet,lifestyle factors,and 10-year mortality in elderly European men and women: the HALE project. JAMA.2004 Sep 22;292(12):1433-9 Cordain L. Eaton SB.Sebastian A.Mann N,Lindeberg S, Watkins BA.OKeefe JH, Brand-MillerJ.Onigins and evolutionof the Western diet: health implications for the 2lst century. Am J C/lin Nutr.2005 Feb;81(2):341-54
• "No clear evidence exists that the neutropenic diet makes a difference in overl rates of infection." DeMille et al.The effect of the neutropenic diet in the outpatient setting: a pilot study. Oncol Nurs Forum,2006 Nov 3;33(2):337-43
•  "CONCLUSION: In patients treated in a [protected environment],a neutropenic diet did not prevent major infection or death." Gardner et al.Randomized comparison of cooked and noncooked diets in patients undergoing remission induction therapy for acute myeloid leukemia. J Clin Oncol.2008 Dec 10;26(35):5684-8
•  Ajiada et al. Inerease in inranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cellsafter a mixed meal.AmJ Clin Nur.2004 Apr;79(4):682-90 2Aliada et al. Ghucose ingestion induces an increase in intranuclear nuclear factor kappaB,a fallin cellular inhibitor kappaB,and an increase in tumor necrosis factor alpha messenger RNA by mononuclear cells in healthy human subjects. Merabolism.2006 Sep;55(9):1177-85
• Tunmetal Acue byperglycemia and the iateimmune system climicalclar,and molecular aspet.CriCare Med.2005;3CD:1624-33
• Kmopsaa Mednerneandiet iesyle fetor,and I0-yea moraliyinelderly European men and women: the HALEprojet.JAMA 2004 Sep 22;29212)1433-9
• KruzicheallUSyouns inthe eary sagesofHV disease have lowintakes of somemicronurentsimporan foroptimalimmune functin./Am DierAssoc.2004 Ju;047):1095-101
• Holeal Fuiandvegctableconumptionand isrelationto makers ofinnammationandoxiatve strss inadolesens./Am DierAsoc.209 Mar109C)414-21
• LL. Weler MM Frufand vegetable inake andrisk of uppr respiatory tactinfecion in pregnant women.Publc alh Mar.200Jun25:1-7

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