Front cover:Camellia lanceoleosa has high levels of unsaturated fatty acids in the seeds. In this issue, Gong et al. present the chromosome-scale genome of diploid wild C. lanceoleosa(pp. 881–898).
JIPB:福建农林大学揭示调控植物衰老的表观调控机制
叶片衰老是一个受多基因调控的复杂性状，在这个过程中转录因子以及表观调控子发挥了重要作用，但是这些因素如何协同调控了叶片的衰老过程，目前尚不清楚。
本研究从蛋白质互作入手，发现WHIRLY1可以与HDA15 （a Reduced Potassium Dependence3 (RPD3) /Histone Deacetylase1 (HDA1)-type histone deacetylase）发生相互作用。借助转录组和酰基化组的分析，作者证实了HDA15通过抑制叶片衰老以及开花相关基因的表达来延迟植物叶片衰老以及开花进程，其机制在于HDA15降低了上述基因H3K9ac的水平。
此外作者发现WHIRLY1 and HDA15共定位于 nutrient recycling related genes (e.g., Glutathione S-transferases 10, non-coding RNA, and photosystem II protein D1 synthesizer attenuator PDIL1-2)以及WRKY53 and ELF4的转录起始位点上通过降低上述基因的H3K9ac的水平来抑制它们的表达。上述HDA15表观遗传修饰的变化依赖于WHIRLY1。
小结：本研究揭示了在表观遗传水平上来抑制植物衰老的新机制。
Figure 8. Working model of WHY1 recruiting HDA15 repressing leaf senescence and flowering in Arabidopsis. Multi-omics genome-wide analysis reveals that ssDNA binding protein WHY1 recruits histone deacetylase HDA15 to co-target the regions near the transcription start site (TSS) and co-repress the transcript level of the nutrient recycling related genes (DTX1, GSTF10, ABCC9) and the photosystem II protein D1 synthesizer attenuator PDIL1-2 as well as WRKY53 and ELF4 by removing their H3K9ac, co-repressing leaf senescence and flowering at the early stage of leaf senescence.
原文：WHIRLY1 recruits the histone deacetylase HDA15 repressing leaf senescence and flowering in Arabidopsis
