25只猫α-氯醛糖中毒：临床表现与静脉注射脂肪乳治疗评估
摘要来源：
一校：刘玲
二校：kenda
编辑：百可事乐
摘要
目标
本研究的目的在于描述α-氯醛糖（AC）中毒猫的临床表现和病程，并确定静脉注射（IV）脂肪乳（ILE）治疗是否会影响AC的血清浓度或临床症状。
方法
纳入了一家大学小动物医院收治的疑似AC中毒的猫。将猫随机分为两组：一组使用20% ILE，先按300 mg/kg的剂量在2分钟内推注，然后按1500mg/kg CRI 30分钟以上（IL+组）；另一组使用醋酸林格氏液进行静脉液体治疗（IL−组）。在入院后0、2h、12h和24h采集血清样本，使用新型验证的、定量的超高效液相色谱-串联质谱法检测AC。在采样时记录重要的以及预先定义的临床特征，并使用先前描述过的中毒严重程度评分对患猫进行评分。出院后通过电话访谈评估结果。
结果
共纳入25只猫：IL+组13只，IL−组12只。最常见的临床症状包括震颤（n=22，88.0%）、脑神经缺陷（n=20，80.0%）和心动过缓（n=19，76.0%）。在任何时间点上，IL+组与IL−组的AC浓度或中毒评分变化均无显著差异（P>0.05）。所有猫都在72小时内康复。
结论与相关性
ILE对AC中毒猫的AC血清浓度或临床症状没有任何影响。所有猫在随访期间均存活。对于出现上述神经系统症状急性发作的猫，AC中毒是一种重要的鉴别诊断，预后良好。
原文：
Alpha-chloralose poisoning in 25 cats: clinical picture and evaluation of treatment with intravenous lipid emulsion
Abstract
Objectives
The aims of this study were to describe the clinical picture and progression in cats with alpha-chloralose (AC) intoxication and to determine if treatment with intravenous (IV) lipid emulsion (ILE) influenced either the serum concentration of AC or the clinical signs.
Methods
Cats with suspected AC poisoning admitted to a university small animal hospital were included. The cats were randomised into two groups: one receiving 20% ILE at a dose of 300 mg/kg as a 2 min bolus, followed by a 1500 mg/kg continuous rate infusion over 30 mins (IL+ group) and the other receiving IV fluid therapy with Ringer’s acetate (IL− group). Serum samples were drawn at 0, 2, 12 and 24 h after admission. Samples were tested for AC with a novel validated, quantitative, ultra-high-performance liquid chromatography-tandem mass spectrometry method. Vital and predefined clinical signs were noted at the times of sampling and patients were scored using a previously described intoxication severity score. Telephone interviews were conducted after discharge to assess outcome.
Results
A total of 25 cats were enrolled: 13 cats in the IL+ group and 12 in the IL− group. The most common clinical signs at presentation were tremor (n = 22, 88.0%), cranial nerve deficits (n = 20, 80.0%) and bradycardia (n = 19, 76.0%). No significant difference in AC concentration or change in intoxication score over time was found between the IL+ and IL− groups at any time point (P >0.05). All cats recovered within 72 h.
Conclusions and relevance
ILE did not have any effect on the AC serum concentration or clinical signs in AC-poisoned cats. All cats survived until follow-up. In cats with an acute onset of the described neurological signs, AC intoxication is an important differential diagnosis with an excellent prognosis.
