测定50只健康猫尿液中肾损伤分子-1的参考区间
摘要来源：
https://doi.org/10.1177/1098612X241238923
一校：刘玲
二校：kenda
编辑：百可事乐
摘要
目的
本研究旨在建立健康猫尿液肾损伤分子-1（KIM-1）的参考区间（RI）。
方法
确定猫的病史、体格检查、血压、猫免疫缺陷病毒和猫白血病病毒的血清学状态。进行了全血细胞计数、血清生化分析、尿液分析和肾脏超声检查，并测量了N末端脑钠肽前体、总甲状腺素（TT4）和尿液KIM-1。利用通用线性模型评估年龄、性别、体况评分（BCS）、血压、对称性二甲基精氨酸（SDMA）、血清肌酐（SCr）、磷、TT4、尿比重（USG）和肾脏中矢状长度对尿液KIM-1的影响，进而计算RI。
结果
在招募的69只猫中，有50只符合纳入标准。其中，有35只公猫和15只母猫，平均年龄4.3岁（范围1.0-12.3岁），平均体重为5.11kg（范围2.52-8.45kg），平均BCS为6/9（范围3-8）。血清SDMA 的平均浓度为11.0 µg/dl（范围2-14）、SCr的平均浓度为88.5 µmol/l（范围47-136）、磷的平均浓度为1.41 mmol/l（范围0.8-2.2）和TT4的平均浓度为 32.0 nmol/l（范围17-51）。平均USG为1.057（范围1.035-1.076），左肾中矢状长度中位数为3.50 cm（范围2.94-4.45），右肾中矢状长度中位数为3.70 cm（范围3.06-4.55）。推断尿液KIM-1的RI为0.02-0.68。USG是尿液KIM-1的重要预测因子（P<0.001）。单独来看，年龄、性别、血压、BCS、SDMA、SCr、磷、TT4和肾脏长度均不是尿液KIM-1的显著预测因子。在多因素模型中，若与USG结合使用时，SDMA浓度可预测尿液KIM-1（P=0.030）。
结论与临床相关性
尿液浓度与尿液KIM-1显著相关，这是在解释可能存在肾损伤的猫的检测结果时需要考虑的一个重要因素。
原文：
Determination of the reference interval for urine kidney injury molecule-1 in 50 healthy cats
Abstract
Objectives
The aim of the present study was to establish a reference interval (RI) for urine kidney injury molecule-1 (KIM-1) in healthy cats.
Methods
History, physical examination, blood pressure, and feline immunodeficiency virus and feline leukemia virus serology status were determined. A complete blood cell count, serum biochemical profile, urinalysis and kidney ultrasound were performed, and N-terminal pro-brain natriuretic peptide, total thyroxine (TT4) and urine KIM-1 were measured. An RI was calculated and the effect of age, sex, body condition score (BCS), blood pressure, symmetric dimethylarginine (SDMA), serum creatinine concentration (SCr), phosphorus, TT4, urine specific gravity (USG) and mid-sagittal kidney length on urine KIM-1 was evaluated using a general linear model.
Results
Of 69 recruited cats, 50 met the inclusion criteria. There were 35 male cats and 15 female cats, with a median age of 4.3 years (range 1.0–12.3), median weight of 5.11 kg (range 2.52–8.45) and median BCS of 6/9 (range 3–8). The median serum concentrations were SDMA 11.0 µg/dl (range 2–14), SCr 88.5 µmol/l (range 47–136), phosphorus 1.41 mmol/l (range 0.8–2.2) and TT4 32.0 nmol/l (range 17–51). Median USG was 1.057 (range 1.035–1.076), mid-sagittal left kidney length was 3.50 cm (range 2.94–4.45) and mid-sagittal right kidney length was 3.70 cm (range 3.06–4.55). The derived RI for urine KIM-1 was 0.02–0.68. USG was a significant (P <0.001) predictor of urine KIM-1. Individually, age, sex, blood pressure, BCS, SDMA, SCr, phosphorus, TT4 and mid-sagittal kidney length were not significant predictors of urine KIM-1. In a multivariate model, if combined with USG, SDMA concentration was predictive (P = 0.030) of urine KIM-1.
Conclusions and relevance
Urine concentration was significantly correlated with urine KIM-1, which will be an important consideration when interpreting findings in cats with potential kidney injury.
