21只局部晚期鼻平面鳞状细胞癌猫接受电化学治疗后的疗效和不良事件
摘要来源：https://doi.org/10.1177/1098612X241248043
一校：刘玲
二校：郭嘉恩
摘要
目的
方法
结果
结论与临床相关性
原文：
Study of feline immunodeficiency virus prevalence and expert opinions on standards of care
摘要来源：https://doi.org/10.1177/1098612X241248043
Abstract
Abstract
Objectives
Squamous cell carcinoma (SCC) is the most common tumour in the nasal planum of cats. Surgery has traditionally been the treatment of choice but might not be feasible in locally advanced scenarios. Electrochemotherapy (ECT) has shown good control in superficial tumours, but there is a lack of robust information about efficacy in locally advanced cases. The aim of this study was to assess the safety and efficacy of ECT in the treatment of locally advanced stage nasal planum SCC in cats.
Methods
The clinical database of a veterinary referral hospital was searched retrospectively for cats diagnosed with a locally advanced nasal planum SCC (T3N0M0 or T4N0M0) that had received ECT. Local response, adverse events and outcome were documented. The data were evaluated by inferential statistics and correlations between response, recurrence, feline immunodeficiency virus/feline leukaemia virus status, number of treatments, voltage and severity of adverse events, with Kaplan–Meier curves and log-rank tests. Statistical significance was set at P <0.05.
Results
In total, 21 cats were enrolled over a 4-year period. Nineteen cats achieved a complete response (CR) and two cats a partial response (PR) for an overall response rate of 100%. Cats achieving a CR had a median disease-free interval of 182 days (range 128–327) and those with a PR had a median progression-free survival of 156.5 days (range 122–191). The median time to progression was not reached. The overall survival was 453 days for a median follow-up of 341 days (range 191–989). Of the cats, 62% had grade 3 or 4 toxicities, but no deaths due to the treatment were documented. Only voltage was correlated with longer survival (P = 0.001).
Conclusions and relevance
ECT appears to be an effective treatment for feline nasal planum SCC and could be considered a first-line therapy for locally advanced cases. Toxicities reported can be severe in the short term and these could be secondary to more invasive lesions and equipment used.
