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Bifidobacterium breve modulates lactic acid to curtail Escherichia coli expansion and alleviate inflammatory bowel disease
Xiaoxiang Gaoa,b, Yuxuan Xiaa,b, Xiaoxuan Suna,b, Wenxuan Doua,b, Ruimin Chena,b, Pan Huanga,b, Leilei Yua,b, Fengwei Tiana,b, Jianxin Zhaoa,b, Wei Chena,b,c, Qixiao Zhaia,b,*
a State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu, 214122, PR China
b School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, PR China
c National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu, 214122, PR China
*Corresponding author.
Abstract
Inhibition of the abnormal proliferation of Escherichia coli is crucial for alleviating inflammatory bowel disease. Due to the complexity of the gut microbiota, specifically targeting and inhibiting particular microbes is a challenging task. One approach involves screening for probiotics that antagonize E. coli; however, this process often requires extensive in vitro experiments using a vast pool of probiotics. In this study, we employed a genome-scale metabolic prediction model to predict the interactions between 803 strains of microbes and E. coli. The results indicated that Bifidobacterium breve and Bifidobacterium animalis exhibited the most potent inhibitory effects. In vitro antibacterial assays and mouse experiments validated the inhibitory efficacy of B. breve CCFM1369. Additionally, B. breve CCFM1369 demonstrated the ability to inhibit key gene Ldha and HIF-2α and reduce the luminal lactate concentration, thereby diminishing the colonization capacity of E. coli. These findings support the potential application of B. breve in the alleviation of colitis.
GAO X X, XIA Y X, SUN X X, et al. Bifidobacterium breve modulates lactic acid to curtail Escherichia coli expansion and alleviate inflammatory bowel disease[J]. Food Bioscience, 2024, 61: 104626. DOI:10.1016/j.fbio.2024.104626.
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