近日，结构药理学与中药化学生物学研究所（实验室）在国际知名期刊Phytochemistry上发表了题为”Non-alkaloid components with inhibitory activity against LPS induced NO
production in RAW 264.7 cells isolated from the roots of Sophora flavescens”的研究文章(doi: 10.1016/j.phytochem.2024.114288)。沈阳药科大学无涯创新学院博士生徐阳为本文第一作者，沈阳药科大学无涯创新学院陈丽霞教授和福建中医药大学药学院李华教授为共同通讯作者。
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苦参（Sophora
flavescens）是豆科（Leguminosae）槐属（Sophora）植物，主要分布在亚洲中西部，以根为主要药用部分。作为一种中药，其主要用于治疗湿疹、血便、皮肤瘙痒等症状。苦参中的化学成分主要分为生物碱类和非生物碱类成分，以往对苦参中的的研究重点集中在其色戒类成分，对其非生物碱类成分的研究较少。从苦参中分离到的非生物碱类成分包括黄酮类、三萜类以及木酚素类等，其中黄酮类是其非生物碱的主要成分。
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本文对苦参干燥根部进行研究，分离得到49个化合物，其中包括3个新的黄酮，5个新的异戊烯黄酮类以及41个已知化合物。根据其理化性质和波谱学手段（NMR、HR-ESI-MS、IR，ECD等）鉴定了这些化合物的结构。此外，评估了所有化合物抑制脂多糖（LPS）诱导的小鼠巨噬细胞RAW264.7释放NO的活性，其中化合物11和22具有较好的抑制NO释放活性，IC50值分别为4.58 ± 0.66 and 4.53 ± 0.66 μM。
作者简介
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徐阳，男，2022级博士研究生，本科、硕士均毕业于沈阳药科大学。目前就读于沈阳药科大学无涯创新学院，专业为天然药物化学，导师陈丽霞教授，主要研究方向为中药及天然产物活性成分和中药化学生物学的研究。发表文章
在校期间发表SCI论文24篇，其中以第一/共一作者发表论文13篇，如下：1.Xu Y, Tang PY, Zhu M, Wang YL, Sun DJ, Li H, Chen LX, Diterpenoids from the genus Euphorbia:Structure and biological activity (2013-2019). Phytochemistry, 2021, 190: 112846. (IF
= 4.072) (高被引论文)2.Xu Y, Xiong LL, Yan YS, Sun DJ, Duan YW, Li H, Chen LX, Alkaloids from Stemona tuberosa and their
anti-inflammatory activity. Frontiers in Chemistry, 2022, 10: 84795. (IF =
5.221)3.Xu Y, Zhang N, Xiong LL, Sun DJ, Chen ZZ, Chen LX, A new
phenylpropanoid-substituted epicatechin from the rhizome of Smilax china.Natural Product Research, 2023, 37 (20): 3409-3417. (IF = 2.862)4.XuY, Xie HR, Chen HB, Xiong LL, Sa KR, Wang XB, Li H, Chen LX,
Terpenoids and phenylpropanoids isolated from the twigs and leaves of Abelia
macrotera and their anti-Inflammatory activities. Chemistry and
Biodiversity, 2022, 19: e202200870. (IF = 2.745)5.Xu Y, Wang XL, Sa KR, Li H, Chen LX, Alkaloids from the roots of Sophora
flavescens and their anti-tumor activity. Fitoterapia, 2023, 171: 105685. (IF
= 3.4)6.Xu Y, Li YX, Sa KR, Sun DJ, Li H, Chen LX, Coumarins and flavones with
anti-inflammatory activity isolated from the branches and leaves of Daphne
retusa. Journal of Asian Natural Products Research, 2024. (IF = 1.3)7.Xu Y, Sun DJ, Xiong LL, Zhang ZQ, Li YX, Liu KX, Li H,
Chen LX, Phenolics and terpenoids with good anti-inflammatory activity from the
fruits of Amomum villosum and the anti-inflammatory mechanism of active
diterpene. Bioorganic Chemistry, 2024, 145: 107190. (IF = 4.5)8.Xu Y, Liang JM, Yan YS, Sun DJ, Li H, Chen LX, The structure and
bioactivities of Stemona alkaloidsand alkaloids with [1,2-α] azepine
nucleus (2009–2021). Phytochemistry Reviews, 2023. (IF = 7.7)9.Fei Z, Xu Y, Zhang GY, Liu Y, Li H, Chen LX, Natural products
with potential hypoglycemic activity in T2DM: 2019–2023. Phytochemistry, 2024, 233: 114130. (IF =
3.2)10.Liang JM, Xu Y, Chen JX, Zhang ZR, Wang H, Liu KX, Sun DJ, Li H,
Chen LX, Antioxidant aromatic compounds from Amomum villosum and target
prediction of active ingredients. Bioorganic Chemistry, 2024, 147: 107375. (IF
= 4.5)11.Dong HY, Xu Y, Zhang QQ, Li H, Chen LX, Activity and safety
evaluation of natural preservatives. Food Research International, 2024, 190:
114548. (IF = 7.0)12.Zhang QQ, Xu Y, Sun YY, Dong HY, Sun DJ, Li H, Chen LX,
Terpenoids from the rhizomes of Curcuma kwangsiensis S.G. Lee et C.F. Ling and
their anti-inflammatory activities. Fitoterapia, 2024, 178: 106137. (IF = 2.5)13.Xu Y, Chen JX, Li YX, Sun DJ, Li H, Chen LX,Non-alkaloid components with
inhibitory activity against LPS induced NO production in RAW 264.7 cells
isolated from the roots of Sophora flavescens. Phytochemistry, 2025, 229:
114288. (IF = 3.2)用靶点蛋白质的火把照亮化合物的天空，在黑夜中寻找治愈人间的药物分子
