招聘岗位：生信专家、博后/助理研究员
工资及福利待遇按单位有关规定执行，科研助理或助理研究员的岗位和编制根据简历和单位面试确定。
待遇福利
课题组长黄鑫博士简介
上海交通大学医学院，上海市第一人民医院临床研究院、疑难疾病精准研究中心PI、课题组长。
美国St. Jude Children’s Research Hospital，Garwood Fellowship博士后。中国科学院上海生命科学研究院博士。
研究方向：发育和发育异常导致的疾病如白血病、儿童实体瘤等。
邮箱：xinhuang16china@gmail.com（有意请发个人简历至此邮箱）。
黄鑫博士的研究围绕发育和发育异常导致的疾病如白血病、儿童实体瘤等，进行机制研究和新靶向策略的开发：
1）通过基于发育和多组学的系统生物学方法，利用生物物理，细胞与分子生物学等‘干湿’结合的手段，发现并从机制上验证多种肿瘤的新靶点和克服药物抗性的联合用药策略，推动了多个国内外临床转化试验。
2）进行了肿瘤特异性PROTAC研究，使其仅靶向肿瘤细胞而不影响正常组织。 黄鑫博士以第一作者在Cancer Cell 、Developmental Cell、Nature Communications等期刊上发表论文，被ScienceDaily, BioArt等国内外多家主流新闻媒体报道。
目前课题组研究聚焦
1）通过干湿’结合的手段，利用肿瘤临床队列发现靶向发育阶段、克隆异质性、肿瘤微环境等的药物靶点，进行功能及机制研究，为诊断和治疗的临床转化提供新的策略。
2） 在多能性干细胞的细胞命运决定、表观调控、转化研究等前沿领域开展合作探索。
代表性成果
向上滑动阅览
1. Huang, X. *, Li Y*, Zhang J*, Yan L, Zhao H, Ding L, Bhatara S, Yang X, Yoshimura S, Yang W, Karol SE, Inaba H, Mullighan C, Litzow M, Zhu X, Zhang Y, Stock W, Jain N, Jabbour E, Kornblau SM, Konopleva M, Pui CH, Paietta E, Evans W, Yu J, Yang JJ. Single-cell systems pharmacology identifies development-driven drug response and combination therapy in B cell acute lymphoblastic leukemia. Cancer Cell 42(4):552-567.e6 (2024).
https://doi.org/10.1016/j.ccell.2024.03.003
2. Patel, A. G. *, Chen, X. *, Huang, X. *, Clay, M. R., Komorova, N., Krasin, M. J., Pappo, A., Tillman, H., Orr, B. A., McEvoy, J., Gordon, B., Blankenship, K., Reilly, C., Zhou, X., Norrie, J. L., Karlstrom, A., Yu, J., Wodarz, D., Stewart, E. & Dyer, M. A. The myogenesis program drives clonal selection and drug resistance in rhabdomyosarcoma. Dev Cell 57, 1226-1240 e1228 (2022). https://doi.org:10.1016/j.devcel.2022.04.003
3. Yang, S. W. *, Huang, X. *, Lin, W., Min, J., Miller, D. J., Mayasundari, A., Rodrigues, P., Griffith, E. C., Gee, C. T., Li, L., Li, W., Lee, R. E., Rankovic, Z., Chen, T. & Potts, P. R. Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases. Nat Commun 11, 4931 (2020). https://doi.org:10.1038/s41467-020-18708-x
4. Huang, X., Zheng, Y., Zhang, F., Wei, Z., Wang, Y., Carrell, R. W., Read, R. J., Chen, G. Q. & Zhou, A. Molecular Mechanism of Z alpha1-Antitrypsin Deficiency. J Biol Chem 291, 15674-15686 (2016). https://doi.org:10.1074/jbc.M116.727826
5. Anand G. Patel et al. A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity bioRxiv, (2024)
https://doi.org/10.1101/2024.01.07.574538
6. Li, Z., Chang, T. C., Junco, J. J., Devidas, M., Li, Y., Yang, W., Huang, X., Hedges, D. J., Cheng, Z., Shago, M., Carroll, A. J., Heerema, N. A., Gastier-Foster, J. M., Wood, B. L., Borowitz, M. J., Sanclemente, L., Raetz, E. A., Hunger, S. P., Feingold, E., Rosser, T. C., Sherman, S. L., Loh, M. L., Mullighan, C. G., Yu, J., Wu, G., Lupo, P. J., Rabin, K. R. & Yang, J. J. Genomic landscape of Down syndrome-associated acute lymphoblastic leukemia. Blood (2023). https://doi.org:10.1182/blood.2023019765
7. Ding, L., Shi, H., Qian, C., Burdyshaw, C., Veloso, J. P., Khatamian, A., Pan, Q., Dhungana, Y., Xie, Z., Risch, I., Yang, X., Huang, X., Yan, L., Rusch, M., Brewer, M., Yan, K. K., Chi, H. & Yu, J. scMINER: a mutual information-based framework for identifying hidden drivers from single-cell omics data. bioRxiv, 2023.2001. 2026.523391 (2023). https://doi.org:10.1101/2023.01.26.523391
8. Zhao, X., Wang, P., Diedrich, J. D., Smart, B., Reyes, N., Yoshimura, S., Zhang, J., Yang, W., Barnett, K., Xu, B., Li, Z., Huang, X., Yu, J., Crews, K., Yeoh, A. E. J., Konopleva, M., Wei, C. L., Pui, C. H., Savic, D. & Yang, J. J. Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia. Nat Commun 13, 5401 (2022). https://doi.org:10.1038/s41467-022-33143-w
9. Li, J., Dai, C., Xie, W., Zhang, H., Huang, X., Chronis, C., Ye, Y. & Zhang, W. A One-step strategy to target essential factors with auxin-inducible degron system in mouse embryonic stem cells. Front Cell Dev Biol 10, 964119 (2022). https://doi.org:10.3389/fcell.2022.964119
10. Gocho, Y., Liu, J., Hu, J., Yang, W., Dharia, N. V., Zhang, J., Shi, H., Du, G., John, A., Lin, T. N., Hunt, J., Huang, X., Ju, B., Rowland, L., Shi, L., Maxwell, D., Smart, B., Crews, K. R., Yang, W., Hagiwara, K., Zhang, Y., Roberts, K., Wang, H., Jabbour, E., Stock, W., Eisfelder, B., Paietta, E., Newman, S., Roti, G., Litzow, M., Easton, J., Zhang, J., Peng, J., Chi, H., Pounds, S., Relling, M. V., Inaba, H., Zhu, X., Kornblau, S., Pui, C. H., Konopleva, M., Teachey, D., Mullighan, C. G., Stegmaier, K., Evans, W. E., Yu, J. & Yang, J. J. Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia. Nat Cancer 2, 284-299 (2021). https://doi.org:10.1038/s43018-020-00167-4
11. Zhu, Z., Li, C., Zeng, Y., Ding, J., Qu, Z., Gu, J., Ge, L., Tang, F., Huang, X., Zhou, C., Wang, P., Zheng, D. & Jin, Y. PHB Associates with the HIRA Complex to Control an Epigenetic-Metabolic Circuit in Human ESCs. Cell Stem Cell 20, 274-289 e277 (2017). https://doi.org:10.1016/j.stem.2016.11.002
12. Wei, H., Cai, H., Wu, J., Wei, Z., Zhang, F., Huang, X., Ma, L., Feng, L., Zhang, R. & Wang, Y. Heparin binds lamprey angiotensinogen and promotes thrombin inhibition through a template mechanism. J Biol Chem 291, 24900-24911 (2016).
13. Liu, C. X., Yin, Q. Q., Zhou, H. C., Wu, Y. L., Pu, J. X., Xia, L., Liu, W., Huang, X., Jiang, T., Wu, M. X., He, L. C., Zhao, Y. X., Wang, X. L., Xiao, W. L., Chen, H. Z., Zhao, Q., Zhou, A. W., Wang, L. S., Sun, H. D. & Chen, G. Q. Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells. Nat Chem Biol 8, 486-493 (2012). https://doi.org:10.1038/nchembio.935
14. Shi, Y., Hu, G., Su, J., Li, W., Chen, Q., Shou, P., Xu, C., Chen, X., Huang, Y., Zhu, Z., Huang, X., Han, X., Xie, N. & Ren, G. Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair. Cell Res 20, 510-518 (2010). https://doi.org:10.1038/cr.2010.44
2024年度国自然医学部50大科研热点中标数统计如下：
本团队从国自然、省市级课题申报、学术代表作规划、实验方案设计、科研技能教育培训等提升年轻科研者科研水平，真正掌握国自然课题设计的核心要点、精妙逻辑和标书撰写技巧，提高标书水平和质量，最终中标国自然。
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