Research Articles-August 10th

2024-08-10 20:34   日本  


Research Articles 

1. Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases (Highlight by Research Briefing)

Click editing uses DNA polymerases, HUH endonucleases and oligonucleotide templates for genome modification.
原文链接 https://www.nature.com/articles/s41587-024-02324-x 
Research Briefing: Precise and versatile genome editing with click editors
原文链接 https://www.nature.com/articles/s41587-024-02340-x 

2. Large-scale discovery of chromatin dysregulation induced by oncofusions and other protein-coding variants

The effects of oncofusions and other protein variants on chromatin remodeling are identified by PROD-ATAC.
原文链接 https://www.nature.com/articles/s41587-024-02306-z 

3. Signal amplification by cyclic extension enables high-sensitivity single-cell mass cytometry

Mass cytometry with signal amplification enables measurement of low-abundance proteins.
原文链接 https://www.nature.com/articles/s41587-024-02316-x 

4. A CAR enhancer increases the activity and persistence of CAR T cells

Chimeric antigen receptor T cell efficacy is enhanced with an interleukin 2-recruiting molecule.
原文链接 https://www.nature.com/articles/s41587-024-02313-0
5. Enhancing siRNA efficacy in vivo with extended nucleic acid backbones

siRNA stability and efficacy are improved by a backbone modification.

原文链接 https://www.nature.com/articles/s41587-024-02336-7

6. Fast, sensitive detection of protein homologs using deep dense retrieval (Highlight by Research Briefing)
Protein homologs in large databases are rapidly identified with an alignment-free pipeline. (详情请见中文导读页面)
原文链接 https://www.nature.com/articles/s41587-024-02353-6 
Research Briefing: Protein language model enables fast and sensitive remote homolog detection
原文链接 https://www.nature.com/articles/s41587-024-02359-0 


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NBiotechnology
Nature Biotechnology 《自然生物技术》期刊致力于服务科学界,探索尖端科技与生命科学的交汇之处。 我们将涵盖生物学, 生物医学, 农业和环境领域,为相关最新研究成果的发布提供平台。《自然生物技术》期刊成立于1996年。
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