Research Articles-June 25th

2024-06-26 05:10   英国  

Research Articles

1. In vivo AAV–SB-CRISPR screens of tumor-infiltrating primary NK cells identify genetic checkpoints of CAR-NK therapy (Highlight by Research Briefing, 详情请见中文导读页面) 

The antitumor efficacy of chimeric antigen receptor natural killer cells is enhanced by genetic engineering. 
原文链接 https://www.nature.com/articles/s41587-024-02282-4 
Research Briefing: CRISPR screens of tumor-infiltrating NK cells identify genetic checkpoints for CAR-NK therapy
原文链接 https://www.nature.com/articles/s41587-024-02319-8 

2. Strain tracking in complex microbiomes using synteny analysis reveals per-species modes of evolution (Highlight by Research Briefing)

The evolution of microbial strains is revealed by analyzing structural variation.
原文链接 https://www.nature.com/articles/s41587-024-02276-2 
Research Briefing: Tracking gene order provides a new perspective on intraspecific evolution in microbiotas
原文链接 https://www.nature.com/articles/s41587-024-02277-1 

3. Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction

Benchmarking of tumor subclonal reconstruction algorithms finds that interalgorithm variability overwhelms intertumor variability and identifies key quality metrics.
原文链接 https://www.nature.com/articles/s41587-024-02250-y

4. High-yield porphyrin production through metabolic engineering and biocatalysis

Porphyrins are produced at scale through metabolic engineering and optimization of CPIII purification.
原文链接 https://www.nature.com/articles/s41587-024-02267-3 


Brief Communication 

Machine learning prediction of prime editing efficiency across diverse chromatin contexts
A machine learning model for prime editing efficiency prediction takes into account chromatin context.
原文链接 https://www.nature.com/articles/s41587-024-02268-2 




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NBiotechnology
Nature Biotechnology 《自然生物技术》期刊致力于服务科学界,探索尖端科技与生命科学的交汇之处。 我们将涵盖生物学, 生物医学, 农业和环境领域,为相关最新研究成果的发布提供平台。《自然生物技术》期刊成立于1996年。
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