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专刊简介

Polysaccharides have gained significant attention in tissue engineering for their dual role in promoting tissue regeneration and preventing microbial infections through antibiofilm and antifouling properties. Biofilm formation on tissue scaffolds and implants can lead to severe complications, including infections and implant failure, making it essential to integrate bacterial features into biomaterials. Naturally derived polysaccharides, such as chitosan, alginate, and hyaluronic acid, offer excellent biocompatibility, biodegradability, and inherent antimicrobial activity, making them ideal candidates for use in medical applications. For instance, chitosan exhibits strong antibacterial properties by disrupting bacterial cell membranes and inhibiting biofilm formation on tissue scaffolds. Further enhancing polysaccharides' antibiofilm and antifouling properties is possible by functionalizing them with antimicrobial agents, such as peptides and nanoparticles. As well as preventing bacterial adhesion, polysaccharides can form protective barriers that support cell attachment and tissue growth. The versatility of these materials allows for the development of multifunctional tissue scaffolds that promote healing while simultaneously protecting against bacterial colonization. A polysaccharide-based antibiofilm and antifouling strategy could provide safer, more effective tissue engineering constructs with enhanced resistance to microbial contamination.

The use of polysaccharides for antibiofilm and antifouling bacterial applications in tissue engineering is challenged by variability in antibacterial efficacy, with some polysaccharides requiring functionalization. It can be challenging to maintain biocompatibility during such modifications. Polysaccharides' long-term stability in biological environments is also a concern, since degradation can reduce their antibacterial effectiveness. It is also difficult to preserve antimicrobial activity while controlling degradation rates. Functionalized polysaccharides continue to face scalability and cost-effective production challenges. This theme would focus on the development, functionalization, and application of polysaccharides as antibiofilm and antifouling agents, emphasizing their role in promoting biocompatibility, preventing bacterial infections, and enhancing tissue engineering outcomes. Potential topics included, but not limited,

Polysaccharide-based hydrogels in antibiofilm and antifouling applications in tissue scaffolds

Functionalization of polysaccharides with antimicrobial peptides in bacterial properties for tissue engineering

Polysaccharide-coated nanoparticles in targeted antibiofilm activity for tissue engineering

Natural polysaccharides in sustainable antifouling coatings for biomedical implants

Polysaccharides in 3D-Bioprinted for antimicrobial performance of tissue engineering

Polysaccharide-based antifouling coatings for cardiovascular tissue engineering

Polysaccharides in combination with photothermal therapy for antibiofilm applications

Immobilization of enzymes on polysaccharides in biofilm degradation for tissue constructs

Polysaccharides self-healing hydrogel for skin regeneration

Polysaccharides for cartilage tissue engineering repair

客座编辑

Dr. S. Anandhavelu

Assistant Professor, Department of Applied Chemistry, Sri Venkateswara College of Engineering, India.

投稿指南

Manuscripts should be submitted online at https://www2.cloud.editorialmanager.com/ijbiomac/default2.aspx 

Please select “VSI: Antibacterial Polysaccharides" when submitting your manuscript to this special issue and indicate the actual article type in the cover letter.

Deadline for manuscript submission: 31 August 2025.

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