近日，Life Medicine第2卷第5期正式在线发布。本期共收录新闻观点（News & Opinion）1篇、亮点（Research Highlight）1篇、论坛（Forum）1篇、研究长文（Article）4篇以及研究短文（Letter）2篇。The heart is the powerhouse of the human circulatory system. As age progresses, the heart undergoes a gradual aging process, depicted in the figure as a clock-shaped heart. Scientists explore functional biomarkers (depicted as a forest in the figure) reflecting cardiac aging, including decreased systolic function, reduced diastolic function, etc. Structural biomarkers (depicted as mountains in the figure) encompass concentric cardiac remodeling, coronary artery calcification, etc. Humoral biomarkers (depicted as rivers in the figure) such as IL-1β, IL-6, NT-proBNP aid in assessing the cardiac aging status. These cardiac aging biomarkers help to predict the risk of age-related cardiac diseases, and contribute to the prevention and treatment of such conditions. Just as the figure alludes to the myth of “Kua Fu Chasing the Sun," scientists exhibit a similar determination in their pursuit, competitively advancing in the study of cardiac aging biomarkers, unwaveringly exploring the field.心脏是人体循环系统的动力中枢。随着年龄增长，心脏逐渐衰老（图中表盘形状心脏）。科学家们通过寻找反映心脏衰老的功能标志物（图中树林），包括收缩功能减退、舒展功能下降等；结构标志物（图中高山），包括左室向心性重塑、冠状动脉钙化等；体液标志物（图中河流），包括IL-1β，IL-6，NT-proBNP等；有助于评估心脏的功能状态，预测发生心脏衰老相关疾病的风险，防治心脏衰老相关疾病。正如图中所引用的“夸父逐日”典故，科学家们具有和“夸父”一样的坚定，在心脏衰老标志物的研究中，与时间竞走，坚持不懈地探索。Brain assembloid: a human model for neural circuits research
In situ neuronal regeneration: the potential of astrocytes
胶质细胞到神经元的细胞身份转换能恢复部分神经元功能
A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement
Vitamin C derivative/AA2P promotes erythroid differentiation by upregulating CA1Efficient repair of human genetic defect by CRISPR/Cas9-mediated interlocus gene conversion
CRISPR/Cas9介导的基因转换高效修复β-地中海贫血遗传突变Deubiquitination of SARM1 by USP13 regulates SARM1 activation and axon degeneration去泛素化酶USP13调控SARM1激活和神经轴突退化Secretagogin regulates asynchronous and spontaneous glutamate release in hippocampal neurons through interaction with Doc2α
SCGN与Doc2α相互作用促进小鼠海马神经元的非同步和自发谷氨酸释放Mutations in TUBA4A lead to human zygotic arrest and early developmental failure
Paeoniflorin relieves arterial stiffness induced by a high-fat/high-sugar diet by disrupting the YAP-PPM1B interaction
https://academic.oup.com/lifemedi/issue/2/5
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Life Medicine是由高等教育出版社联合牛津大学出版社共同创办的面向基础和转化医学领域的综合性、开放获取期刊，是Life系列旗舰期刊之一。Life Medicine致力于推广改善人类健康的基础研究工作，涵盖与健康和疾病密切相关的机制、预警与干预研究、以及以改善生命健康为目标的新药研发及技术创新成果。
Life Medicine聚焦具有高度创新性和高领域关注度的人类健康和医学研究，发表与人类健康密切相关的基础医学研究最新成果，包括但不限于健康科学、智能医学、生殖医学、老年医学、再生医学、药理学、遗传性疾病、传染性疾病、心血管疾病、呼吸系统疾病、消化系统疾病、神经系统疾病、免疫疾病，致力于为医学基础研究及临床转化提供学术交流和创新的平台。
Life Medicine编辑团队诚挚邀请广大科研人员将高质量的科研成果投稿至本期刊。
