高度致病性耐药菌感染严重阻碍了伤口愈合过程，并对人类健康构成巨大威胁。将多种抗菌策略整合到纳米结构材料中已被证明在提高耐药菌治疗效率方面具有极大潜力。
近日，西北工业大学徐飞教授和贾庆岩副教授等人在Science China Materials发表研究论文，通过一步共聚和碳化的方法制备了一种多功能蛋黄-蛋壳结构纳米复合材料（Au@HCN），该材料由金（Au）核心和空心碳纳米球（HCN）壳组成。
本文要点
1) Au@HCN对细菌膜的电子掠夺导致细菌膜去极化和活性氧（ROS）代谢增强，在黑暗条件下对耐药菌表现出显著的抗菌效果。2) 在体外近红外（NIR）照射下，协同光热治疗（PTT）显示出显著的抗菌特性（~98%）。3) 在体内感染伤口中，NIR照射下有效消除了耐药菌，从而通过Au@HCN显著的抗菌特性促进了伤口愈合。蛋黄壳Au@HCN在高效对抗多重耐药性方面具有巨大潜力。Figure 1. Schematic illustration of the synthesized Au@HCN used to eliminate highly pathogenic-resistant bacteria in a skin wound infection model.Figure 2. (a) Synthetic process of Au@HCN. (b) TEM image of Au NPs. (c) SEM image of Au@PACP. (d) SEM image of Au@HCN. (e) TEM image of Au@HCN. (f) Particle size distribution of Au@HCN. (g) Zeta potential of HCN and Au@HCN.Figure 3. (a–c) Antibacterial rates of Au@HCN against TRE (a), MRSA (b), VRE (c). (d) Representative optical images of survival bacterial colonies on agar plates after treating by Au@HCN and PBS. (e) SEM images of TRE, MRSA, and VRE after treated by Au@HCN and PBS. Scale bars: 1 μm. The error bars indicate the standard deviation (n = 3).![]()
Figure 4. In vivo MRSA-infected wound treatment. (a) Schematic diagram of infected wound model construction and therapeutic procedure. (b) The digital photographs of infected wound from day 0 to day 4 (diameter of the white ring: 8 mm). (c) Wound closure trends from 0 to 4 days. (d) Wound closure rate on day 4 after different treatments. (e) Quantitative analysis of bacteria colonies from tissues subjected to various treatments. (f) Representative optical image depicting bacterial growth on culture medium following plate coating with mouse wound tissue. (g) Representative H&E staining images of wound tissues after 4 days of different treatments. The error bars indicate the standard deviation (n = 4).Jin Chai, Changzhen Qu, Kunpeng Li, Jiaheng Liang, Qian Zhou, Rong Zhuang, Shuo Wang, Fei Xu, Qingyan Jia, Peng Li. Yolk–shell Au@carbon nanospheres with photothermal and electron-plunder sterilization for infected wound healing. Sci. China Mater. (2024).https://doi.org/10.1007/s40843-024-3151-8
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