基本信息
中文题目：
代谢综合征与非酒精性脂肪性肝炎患者明显的肝纤维化和脂肪变性有关
英文题目：
Metabolic syndrome is associated with significant hepatic fibrosis and steatosis in patients with nonalcoholic steatohepatitis
作者及单位：
Qian-Qian Lia1, Yu-Ting Xiongb1, Danni Wangc1, Ke-Xin Wangb, Chang Guoa, Yi-Ming Fua, Xiao-Xia Niua, Chun-Yan Wanga, Jian-Jun Wanga, Dong Jiab, Zhi-Fang Baia
a
Senior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing 100039, China
b
The PLA 307 Clinical College of Anhui Medical University, The Fifth Clinical Medical College of Anhui Medical University, Hefei 230032, China
c
Central Hospital of Ningcheng County, Chifeng City, Inner Mongolia Autonomous Region 024200, China
如何引用：
Qian-Qian Li, Yu-Ting Xiong, Danni Wang,et al. Metabolic syndrome is associated with significant hepatic fibrosis and steatosis in patients with nonalcoholic steatohepatitis. iLIVER. 2024;3(2):100094.
doi: 10.1016/j.iliver.2024.100094.
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● 本文发表在iLIVER期刊的第3卷第2期，欢迎点击阅读原文阅读和引用。
Keywords
Nonalcoholic steatohepatitis
Metabolic syndrome
Liver biopsy
Hepatic fibrosis
High-risk factor
Abstract
Background and aims：
Nonalcoholic steatohepatitis (NASH), an inflammatory form of non-alcoholic fatty liver disease, can progress to advanced liver fibrosis, cirrhosis, and liver cancer. Metabolic syndrome (MetS) parallels the prevalence of non-alcoholic fatty liver disease/NASH and increases patients’ risk of advanced liver disease. This study aimed to determine whether MetS was associated with the histological progression of NASH.
Methods：
Patients with liver biopsy-proven NASH were retrospectively screened and categorized into two groups for each histological feature: with (<2 points) or without (≥2 points) significant hepatic steatosis/inflammation/fibrosis. Multivariable logistic regression was used to explore the association between MetS and histological features.
Results：
In total, 386 patients with a median age of 33.0 years were enrolled; among them, 35.2% were female, and 41.2% had MetS. The proportion of significant hepatic fibrosis and steatosis in those with MetS was significantly higher than in those without MetS (p < 0.05). Multivariable logistic regression analyses showed that MetS remained significantly associated with significant hepatic fibrosis (adjusted odds ratio: 1.852, 95% confidence interval: 1.042–3.292, p = 0.036), and severe hepatic steatosis (adjusted odds ratio: 2.008, 95% confidence interval: 1.030–3.914, p = 0.041).
Conclusion：
MetS was associated with significant hepatic fibrosis and steatosis in patients with NASH. Our results suggest that NASH patients with MetS should be closely monitored and given targeted intervention and treatment, which may help to prevent disease progression and mitigate the growing burden of NASH.
期刊介绍
iLIVER是由中华人民共和国教育部主管，清华大学主办，清华大学出版社出版，爱思唯尔全球发行的肝病领域开放式英文期刊。本刊旨在传播肝病领域的创新和实践成果，并为从事肝胆系统研究的多学科专家和学者提供核心学术资源。本刊可发表肝胆系统领域中临床医学、转化医学、基础医学和公共卫生的原创研究、荟萃分析、综述、共识和实践指南等研究。主题涵盖范围包括：
● 肝的结构、功能及调节机制的研究；
● 肝胆疾病的基础研究，包括病因、发病机制、病理生理学和预防策略；
● 肝胆疾病的预防、诊断、治疗、康复和慢性病管理；
● 与肝胆疾病流行病学、预防、监测和卫生政策相关的公共卫生研究；
● 肝脏健康相关的转化科学；
● 数据和智能技术在肝病领域的应用；
● 与肝胆疾病相关的临床药物试验和医疗器械临床试验；
● 以肝病为重点的跨学科研究。
为鼓励肝胆领域创新性研究，iLIVER在创刊初期（2022-2024）免收版面费并为接收文章提供免费的英文润色服务！
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