湖南大学化学化工学院冯欣欣课题组 诚招/聘药学、化学、生物等相关领域的硕士研究生、博士研究生、博士后研究员及科研助理若干名。我们是一个跨学科的科研团队，拥有有机化学、药物化学、化学生物学、微生物学、分析化学背景的导师及研究生，并与国内外微生物、药物化学领域的顶尖课题组保持紧密合作。目前，课题组的研究方向主要为具有抵抗细菌耐药性特性（即“抗-耐药性”）的抗菌药物的化学生物学研究。
如果你具备化学、生物、药学、医学等相关专业背景，并希望在学术上更进一步，或者希望开展跨学科研究，欢迎加入我们的团队，一起向科研的更深层次、更高水平迈进。学院和课题组将提供完善的职业规划指导，全方位培养个人能力，全力帮助课题组成员取得学术界或工业界职位。
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课题组简介及近期成果
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耐药性细菌感染是严重影响人类生命健康及社会经济发展的重大问题。世界抗菌药物开发的困境主要源于传统抗生素固有的靶向机制，即其单一性地靶向细菌外膜以内的生物大分子靶点（如关键蛋白）而带来生长抑制性机制。传统抗生素的靶点选择使得细菌易于产生三种常见的耐药性：外膜对抗生素的阻挡作用形成“屏障性耐药”；蛋白靶点的易突变性促使细菌在药物压力下进化产生“进化性耐药”；细菌入侵细胞、以生长静止的休眠菌形式逃逸抗生素攻击的“藏匿性耐药”。由此可见，新一代抗菌药物的开发并非简单的分子结构改造问题，而是从根源上寻找具有“抗-耐药性”的抗菌靶点的关键科学问题。
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导师介绍
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03
应聘条件
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岗位要求：
1. 博士后应聘者35周岁以下，已获得或即将取得博士学位，博士后应聘者博士期间在国际期刊发表优秀SCI论文；
6. 应聘者具有高度工作责任心，积极主动、踏实肯干、富有团队合作精神并热心组内公共事务。
岗位待遇：
申请程序：
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课题组论文
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1. Zhou, Y. et al. Cooperative Membrane Damage as a Mechanism for Pentamidine-Antibiotic Mutual Sensitization. ACS Chem. Biol. 17, 3178-3190 (2022).
2. Lei, E. et al. Potentiation of Vancomycin: Creating Cooperative Membrane Lysis through a "Derivatization-for-Sensitization" Approach. J. Am. Chem. Soc. 144, 10622-10639 (2022).
3. Wang, M. et al. Chemical biology investigation of a triple-action, smart-decomposition antimicrobial booster based-combination therapy against “ESKAPE” pathogens. Science China Chemistry (2024).
4. Chan, H.-C. et al. Structure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosis. Journal of the American Chemical Society 136, 2892-2896 (2014).
5. Li, K. et al. Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases. Journal of Medicinal Chemistry 57, 3126-3139 (2014).
6. Feng, X.X. et al. Antiinfectives targeting enzymes and the proton motive force. Proc. Natl. Acad. Sci. U. S. A. 112, E7073-E7082 (2015).
7. Bai, S.L. et al. A polymeric approach toward resistance-resistant antimicrobial agent with dual-selective mechanisms of action. Sci. Adv. 7, 16 (2021).
8. Zhang, Y. et al. Pyrgos[<i>n</i>]cages: Redefining antibacterial strategy against drug resistance. Sci. Adv. 10, eadp4872 (2024).
9. Chen, Z.Y. et al. An alternatingly amphiphilic, resistance-resistant antimicrobial oligoguanidine with dual mechanisms of action. Biomaterials 275, 10 (2021).
10. Chen, Z.Y. et al. Alternatingly Amphiphilic Antimicrobial Oligoguanidines:Structure-Property Relationship and Usage as the Coating Materialwith Unprecedented Hemocompatibility. Chem. Mater. 34, 3670-3682 (2022).
11. Chen, X.H. et al. Improving the Hemocompatibility of Antimicrobial Peptidomimetics through Amphiphilicity Masking Using a Secondary Amphiphilic Polymer. Adv. Healthc. Mater. 11, 10 (2022).
12. Yang, A. et al. Ligand-Receptor Interaction-Induced Intracellular Phase Separation: A Global Disruption Strategy for Resistance-Free Lethality of Pathogenic Bacteria. Journal of the American Chemical Society (2024).
13. Bai, S.L. et al. Chemical Biology Approach to Reveal the Importance of Precise Subcellular Targeting for Intracellular <i>Staphylococcus aureus</i> Eradication. Journal of the American Chemical Society 145, 23372-23384 (2023).
14. Wang, J.X. et al. Multivalent Display of Lipophilic DNA Binders for Dual-Selective Anti-Mycobacterium Peptidomimetics with Binary Mechanism of Action. CCS Chem. 4, 3573-3586 (2022).
