基于非对称浸润性结构的自泵敷料（SPDs）已发展成为一种用于伤口过量渗液引流的新型有效材料，然而，由于亲、疏水层之间的界面力学稳定性较弱，目前的SPDs容易失去其不对称浸润性。
近日，中国科学院理化技术研究所王树涛研究员和时连鑫副研究员等人在Science China Materials发表研究论文，通过冰模板辅助浸润诱导转移（WET）聚合策略，制备了一种一体化的、具有定向微通道的自泵油水凝胶敷料（SPD-AM），可以加速糖尿病伤口的愈合过程。
1) WET策略使疏水油凝胶层和亲水水凝胶层之间具有强界面力学稳定性，定向排列的微通道大大提高了SPD的导水能力。2) 以糖尿病大鼠模型为例，相比其他敷料，SPD-AM可显著减少细菌定植，降低炎症反应，促进真皮重塑约47.31%，缩短创面愈合时间约1/5，并最终加速糖尿病创面愈合。本研究对开发下一代面向临床应用的具有稳定力学性能的自泵敷料具有重要价值。Figure 1. Design of the integrated SPD-AM for draining biofluids. (a) Schematic diagram showing the preparation of SPD-AM through ice-templating-assisted WET polymerization strategy. (b) SPD-AM features both mechanically stable interfaces and effective draining capability, promoting the healing of diabetic wounds.Figure 2. Interfacial mechanical stability of the SPD prepared by WET strategy. (a, b) Schematic and images showing the peeling interfaces between the adhesive tapes and the different SPD fabricated by WET strategy (left) and electrospinning (right) from the front view (a) and the side view (b). Scale bar, 2 mm. (c) The peeling force of different commercial tapes on the SPD organogel layer. (d) CLSM images showing the morphology of SPD and the residue on the tape before and after peeling. Organogel, dyed red; hydrogel, dyed green. Scale bar, 100 μm.![]()
Figure 3. Liquid draining capability of the SPD-AM. (a) Schematic and images of the droplet (labeled with 0.1% methylene blue) drained by the SPD-AM, SPD-RP, and HD-AM, respectively. Scale bar, 500 μm. (b) Comparison of the water droplet (labeled with 1% fluorescein sodium) wetting areas on SPD-AM, SPD-RP, and HD-AM after 1.0 s, respectively. White circles represent the initial wetting area, and red circles represent the wetting area at 1.0 s. Scale bar, 1 mm. (c, d) Schematic and corresponding dynamic CAs of the water droplet wetting on SPD-AM, SPD-RP, and HD-AM, respectively.![]()
Figure 4. Promotion of diabetic wound healing by the SPD-AM in vivo. (a) The treatment schedule for diabetic wound healing model. (b) Images of the colonization of bacteria after 24 h culture from the wounds treated by the SPD-AM, SPD-RP, HD-AM, and NT after four days. Scale bar, 2 cm. (c) Representative optical images showing the wound healing process during a 10-day treatment by the SPD-AM, SPD-RP, HD-AM, and NT, respectively. Scale bar, 2 mm. (d) Statistical analysis of the wound area during 10-day of post-wounding. Wound sizes at different periods were normalized to day 0 (n ≥ 6). Statistical significance and p values were determined by a two-sided Student’s t-test.Wuyi Xiao, Xizi Wan, Yikai Zhang, Jinze Lan, Lianxin Shi, Shutao Wang. A mechanically stable self-pumping organohydrogel dressing with aligned microchannels for accelerated diabetic wound healing. Sci. China Mater. (2024).https://doi.org/10.1007/s40843-024-2980-1
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