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北京时间
2024年11月12日（周二）
晚上20:00-21:00
2024 Nov. 12th Tuesday
20:00-21:00 (Beijing Time)
Zoom网络研讨会: 843 6931 3262
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Kathy实验室在调控人类早期胚胎发育的基因功能、人类胚胎细胞命运决定的分子机制等领域开创了重要的研究方法，致力于研究人类胚胎发育过程中，基因和信号通路对胚胎、胎盘和卵黄囊分化的调控。此外，Kathy实验室获得了首个国家监管批准，允许在科学研究中对人类胚胎进行基因编辑，此举引起了广泛的社会关注，该研究许可证被收录为伦敦科学博物馆的永久馆藏，实验室的部分科研用品也曾在博物馆展出。Kathy实验室也在探索如何改善不孕症和发育障碍的临床治疗，她在科学政策方面的工作和倡议推动了人类胚胎和干细胞在医学研究中应用伦理的发展。
Kathy在华盛顿大学获得细胞与分子生物学理学学士学位、英语文学学士学位。随后，她在加州大学洛杉矶分校获得博士学位，在此期间，Kathy荣获了美国国立卫生研究院的博士培养资助 (NIH Pre-doctoral Training Grant)、Paul D. Boyer奖学金和Chancellor年度奖学金。博士毕业后，Kathy前往哈佛大学进行博士后研究，并对人类早期胚胎发育产生了浓厚的兴趣。后来，Kathy获得了Loke CTR的“新生代研究”奖学金。2013年，Kathy在医学研究委员会国家医学研究所(即后来的Francis Crick Institute)成立了自己的实验室，继续专注于人类早期胚胎发育的机制研究。
Kathy曾在2019年被提名为布拉瓦特尼克奖(Blavatnik Award)英国生命科学决赛入围者，并在2024年当选为欧洲分子生物学组织（EMBO）成员。
Kathy Niakan is Mary Marshall and Arthur Walton Professor of the Physiology of Reproduction and Director of the Loke Centre for Trophoblast Research at the University of Cambridge. She is also Co-Chair of the Cambridge Reproduction Interdisciplinary Research Centre. From 2021, Kathy has been an Honorary Group Leader at the Babraham Institute and Affiliate Member of the Cambridge Stem Cell Institute. Kathy’s laboratory pioneered approaches to investigate the function of genes that regulate early human development and the molecular mechanisms that direct cell fate in human embryos. Her laboratory is interested in understanding the genes and signalling pathways that regulate the divergence of embryonic versus placenta and yolk-sac cells in human development. Her laboratory obtained the first nationally regulated approval to genetically modify human embryos in research which attracted widespread policy interest. This research licence was acquired as part of the permanent collection at the Science Museum in London, where scientific objects from the laboratory have also been exhibited. Her laboratory seeks to improve the clinical treatment of infertility and developmental disorders, and her work in scientific policy and advocacy informs the ethical use of human embryos and stem cells in research and medicine. Kathy obtained a B.Sc. in Cell and Molecular Biology and a B.A. in English Literature from University of Washington. She obtained her PhD at University of California, Los Angeles, supported by a National Institutes of Health Pre-doctoral Training Grant, Paul D. Boyer Fellowship and a Chancellor’s Dissertation Year Fellowship. She undertook postdoctoral training at Harvard University where she developed an interest in early human development. She was a Loke Centre for Trophoblast Research Next Generation Research Fellow at University of Cambridge. In 2013 she started her laboratory with a focus on mechanisms regulating early human development at the MRC National Institute for Medical Research and subsequently the Francis Crick Institute. Kathy was a Blavatnik Award UK Finalist in Life Sciences (2019) and elected to EMBO membership (2024).
During preimplantation development human embryos are comprised of pluripotent embryonic cells, which eventually form the fetus, and extra-embryonic cells, which contribute to the placenta and yolk sac. The central question we address is what are the molecular mechanisms that regulate these early cell fate choices in human embryos. We are using CRISPR/Cas9-mediated genome editing, TRIM-Away protein depletion, dominant negative mutations and small molecules to dissect the function of genes during human embryogenesis. These methods have enabled us to uncover that the first and second lineage specification events in human embryos. Our work has also uncovered a high frequency of unintended on-target mutations following genome editing in human primary cells. By integrating signalling insights from human blastocysts we have defined human embryonic stem cell culture conditions that more closely recapitulate the embryonic niche. The molecular basis of these early cell lineage decisions are of fundamental importance and have wide-reaching clinical implications for infertility, miscarriages, developmental disorders and therapeutic applications of stem cells.
主讲人近年发表论文摘选 |
Selected Recent Publications
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