Distinguished Scholar Club -- Chenhao Li & Zhenfei Xie

Zhenfei Xie, Ph.D.

Current position: 

Postdoctoral fellow, The Ragon Institute of Mass General, MIT, and Harvard

Biography

Zhenfei received his B.S. in Biological Sciences from Sichuan Agricultural University in 2012, and then received his Ph.D. in Developmental Biology from Shanghai Institute of Biochemistry and Cell Biology in 2018. During his Ph.D., Zhenfei worked on mouse sperm-like cell—haploid embryonic stem cell mediated embryonic development and its application for rapid generation of genetically engineered mouse models with CRISPR-Cas9 under the supervision of Prof. Jin-Song Li. After completing his Ph.D. study, he joined Prof. Yi Zhang lab of Boston Children’s Hospital/Harvard Medical School in 2018 as a postdoctoral research fellow to work on the epigenetic reprogramming in cloned mouse development. After that, he shifted his focus and continued his scientific training in Immunology in Prof. Facundo Batista’s lab of Ragon Institute as a postdoctoral research fellow in 2020 and was promoted as a research scientist in 2023. Currently, his research relates to vaccine studies against infectious disease, particularly on HIV with humanized mouse models.

Talk title

HIV-1 trimer boosters elicit precursors to broadly neutralizing antibodies

Highlighted publications

First- and Co-First Author Publications (*equal contribution)

1. Xie, Z. *, Lin, Y.-C. *, Steichen, J. M. *, Ozorowski, G. *, Kratochvil, S., Ray, R., Torres, J. L., Liguori, A., Kalyuzhniy, O., Wang, X., Warner, J. E., Weldon, S. R., Dale, G. A., Kirsch, K. H., Nair, U., Baboo, S., Georgeson, E., Adachi, Y., Kubitz, M., … Batista, F. D. (2024). mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies. Science, 384(6697), eadk0582. https://doi.org/10.1126/science.adk0582

2. Xie, Z. *, Zhang, W. *, & Zhang, Y. (2022). Loss of Slc38a4 imprinting is a major cause of mouse placenta hyperplasia in somatic cell nuclear transferred embryos at late gestation. Cell Reports, 38(8), 110407. https://doi.org/10.1016/j.celrep.2022.110407

3. Yin, Q. *, Wang, H. *, Li, N. *, Ding, Y. *, Xie, Z. *, Jin, L. *, Li, Y., Wang, Q., Liu, X., Xu, L., Li, Q., Ma, Y., Cheng, Y., Wang, K., Zhong, C., Yu, Q., Tang, W., Chen, W., Yang, W., … Li, J. (2020). Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1. Cell Research, 30(2), 133–145. https://doi.org/10.1038/s41422-019-0264-2

4. Li, H. *, Guo, A. *, Xie, Z. *, Tu, W., Yu, J., Wang, H., Zhao, J., Zhong, C., Kang, J., Li, J., Huang, S., & Shen, L. (2017). Stabilization of mouse haploid embryonic stem cells with combined kinase and signal modulation. Scientific Reports, 7(1), 13222. https://doi.org/10.1038/s41598-017-13471-4

5. Zhong, C. *, Xie, Z. *, Yin, Q. *, Dong, R., Yang, S., Wu, Y., Yang, L., & Li, J. (2016). Parthenogenetic haploid embryonic stem cells efficiently support mouse generation by oocyte injection. Cell Research, 26(1), 131–134. https://doi.org/10.1038/cr.2015.132

6. Zhong, C. *, Yin, Q. *, Xie, Z. *, Bai, M. *, Dong, R. *, Tang, W., Xing, Y.-H., Zhang, H., Yang, S., Chen, L.-L., Bartolomei, M. S., Ferguson-Smith, A., Li, D., Yang, L., Wu, Y., & Li, J. (2015). CRISPR-Cas9-Mediated Genetic Screening in Mice with Haploid Embryonic Stem Cells Carrying a Guide RNA Library. Cell Stem Cell, 17(2), 221–232. https://doi.org/10.1016/j.stem.2015.06.005