Frontier Symposium: New Approaches in Studying Gene Regulation

基因的加工、修饰贯穿了中心法则的全部环节，紧密调节了生物的几乎所有发育过程，其失调也与疾病的发生发展密切相关。研究这一事件有助于理解基因调控在生理层面扮演的功能，为人为干预这一过程以治疗疾病提供思路。

此次研讨会有幸邀请到来自麻省理工学院的两位杰出学者：Menglin Wang博士和Kehui Xiang博士与我们交流最近对于基因调控方面的研究进展。Menglin Wang博士主要聚焦于发展基于脂质体的药物递送手段来干预微生物-肿瘤间的相互作用，从而引发免疫细胞的基因响应和抗原呈递过程，揭示了治疗肿瘤的一个新的潜在策略。Kehui Xiang博士则研究了脊椎动物早期胚胎发育过程中mRNA末端长度的调控机制，以及其对转录和翻译过程的影响，为脊椎动物基因调控的保守性提供了新的范式。欢迎大家届时参加交流！

讲座时间：6:00 - 8:00 pm EDT, Wednesday, April 24th, 2024

讲座地点：Room YC-306, Yawkey Building, Dana-Faber Cancer Institute, 99 Jimmy Fund Way, Boston, MA 02115 （Dinner will be served）

报名链接：https://docs.google.com/forms/d/e/1FAIpQLSc00fQBF658ahXq5UMj4TPgbihm2I_rnfyObS0KLEb1JIw3Kw/viewform?usp=sharing

Menglin Wang, Ph.D.

Current position: 

Postdoctoral Associate

Whitehead Institute for Biomedical Research

Massachusetts Institute of Technology

Talk title: 

Microbe, Host, Gene Regulation in Immunotherapy

Biography:

Dr. Wang earned her bachelor’s degree in Pharmacy and doctoral degree in Pharmaceutical Science from Shenyang Pharmaceutical University and pursued postdoctoral research at University of North Carolina at Chapel Hill and Whitehead Institute for Biomedical Research. Dr. Wang is interested in microbial immunotherapy by employing different modality of gene/drug delivery and remains committed to study infectious diseases and cancer. Dr. Wang focuses on understanding the interaction mechanisms between hosts and microbiome using molecular and genetic methodologies and investigates drug and gene delivery strategies targeting microbial cell infection processes, aiming to develop precise interventions and immunotherapies based on host-microbiome interactions. 

Highlighted publications:

1. Menglin Wang; Benoit Rousseau; Kunyu Qiu; Guannan Huang; Yu Zhang; Hang Su; Christine Le Bihan-Benjamin; Ines Khati; Oliver Artz; Michael B. Foote; Yung-Yi Cheng; Kuo-Hsiung Lee; Michael Z. Miao; Yue Sun; Philippe-Jean Bousquet; Marc Hilmi; Elise Dumas; Anne-Sophie Hamy; Fabien Reyal; Lin Lin; Paul M. Armistead; Wantong Song; Ava Vargason; Janelle C. Arthur; Yun Liu; Jianfeng Guo; Xuefei Zhou; Juliane Nguyen; Yongqun He; Jenny P.-Y. Ting; Aaron C. Anselmo; Leaf Huang; Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses, Nature Biotechnology, 2023: 1-12.

2. Menglin Wang; Yinglei Zhai; Hao Ye; Qingzhi Lv; Bingjun Sun; Cong Luo; Qikun Jiang; Haotian Zhang; Youjun Xu; Yongkui Jing; Leaf Huang; Jin Sun; Zhonggui He; High Co-Loading Capacity and Stimuli-Responsive Release Based on Cascade Reaction of Self-Destructive Polymer for Improved Chemo-Photodynamic Therapy, ACS Nano, 2019, 13(6): 7010-7023.

3. Menglin Wang; Jin Sun; Yinglei Zhai; He Lian; Cong Luo; Lin Li; Yuqian Du; Dong Zhang;Wenya Ding; Shuhong Qiu; Yuhai Liu; Longfa Kou; Xiangfei Han; Rongwu Xiang; Yongjun Wang; Zhonggui He ; Enteric Polymer Based on pH-Responsive Aliphatic Polycarbonate Functionalized with Vitamin E To Facilitate Oral Delivery of Tacrolimus, Biomacromolecules, 2015, 16(4): 1179-1190. 

4. Menglin Wang; Longwei Li; Junxia Xie; Yinghua Sun; Guixia Ling; Zhonggui He; Transdermal Adhesive Patches Loaded with Ketoprofen Evaluated by Dynamic Detection of Percutaneous Absorption, AAPS PHARMSCITECH, 2016, 6(18): 2141-2148.

5. Yang Cui; Michael Z. Miao; Menglin Wang; Qian P. Su; Kunyu Qiu; Liubov Arbeeva; Susan Chubinskaya; Brian O. Diekman; Richard F. Loeser; Yes-associated protein nuclear translocation promotes anabolic activity in human articular chondrocytes, Osteoarthritis and Cartilage, 2023, 31(8): 1078-1090.

6. Yun Liu; Karthik, Tiruthani; Menglin Wang; Xuefei Zhou; Nasha Qiu; Yang Xiong; Chad V. Pecot; Rihe Liu; Leaf Huang; Tumor-targeted gene therapy with lipid nanoparticles inhibits tumor-associated adipocytes and remodels the immunosuppressive tumor microenvironment in triple-negative breast cancer, NANOSCALE HORIZONS, 2021, 6(4): 319-329.

7. Hao Ye; Kaiyuan Wang; Menglin Wang; Rongzheng Liu; Hang Song; Na Li; Qi Lu; Wenjuan Zhang; Yuqian Du; Wenqian Yang; Lu Zhong; Yu Wang; Bohong Yu; Hong Wang; Qiming Kan; Haotian Zhang; Yongjun Wang; Zhonggui He; Jin Sun; Bioinspired nanoplatelets for chemo-photothermal therapy of breast cancer metastasis inhibition, Biomaterials, 2019, 206: 1-12.

Kehui Xiang, Ph.D.

Current position: 

Postdoctoral Associate

Whitehead Institute for Biomedical Research

Massachusetts Institute of Technology

Talk Title: 

Control of poly(A)-tail length and translation in vertebrate oocytes and early embryos

Biography: 

Dr. Xiang earned his bachelor’s degree in Mathematics and Physics from Tsinghua University. He completed his Ph.D. with Dr. Liang Tong and Dr. James Manley in Biological Sciences at Columbia University, where he carried out structural and biochemical studies of transcription-coupled pre-mRNA 3ʹ-end processing. Presently, he is working with Dr. David Bartel as a postdoctoral associate at the Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology. Dr. Xiang's research has been centered on RNA biology and post-transcriptional gene regulation during vertebrate early development. Employing a multidisciplinary approach, he integrates high-throughput system methodologies, RNA and protein biochemistry, functional genomic screens, and machine learning to unravel gene-regulatory mechanisms governing developmental transitions. 

Highlighted publication:

1. Kehui Xiang, Jimmy Ly, David P. Bartel. Control of poly(A)-tail length and translation in vertebrate oocytes and early embryos. Developmental Cell https://doi.org/10.1016/j.devcel.2024.02.007 (2024) 

2. Kehui Xiang, David P. Bartel. The molecular basis of coupling between poly (A)-tail length and translational efficiency. eLife 10:e66493 (2021).

3. Hsin Jing-Ping, Kehui Xiang, James L. Manley. Function and control of RNA polymerase II CTD phosphorylation in vertebrate transcription and RNA processing. Mol. Cell. Biol. 34 2488-2498 (2014).

4. Kehui Xiang, Liang Tong, James L. Manley. Delineating the structural blueprint of the pre-mRNA 3' end processing machinery. Mol. Cell. Biol. 34, 1894-1910 (2014).

5. Kehui Xiang, James L. Manley & Liang Tong. An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. Genes Dev. 26, 2265-2270 (2012).

6. Kehui Xiang, James L. Manley & Liang Tong. The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity. Nat. Commun. 3, 946 (2012).

7. Jeong Ho Chang, Song Xiang, Kehui Xiang, James L. Manley & Liang Tong. Structural and biochemical studies of the 5’ to 3’ exoribonuclease Xrn1. Nat. Struct. Mol. Biol. 18, 270-276 (2011).

8. Kehui Xiang, Takashi Nagaike, Song Xiang, Turgay Kilic, Maia M. Beh, James L. Manley, Liang Tong. Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature 467, 729-733 (2010).