Pharmacopsychiatry
Issue 04 · Volume 57 · July 2024
欢迎阅读本期全部论文。
主编精选,免费阅读
Mohammad TM et al.
Pentoxifylline as a Novel Add-on Therapy for Major Depressive Disorder in Adult Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
背景 有证据表明,免疫失调与重度抑郁症 (MDD) 之间存在关联。磷酸二酯酶抑制剂己酮可可碱 (PTX) 已被证明可以降低促炎活性。本研究旨在评估在 MDD 患者中,将 PTX 作为西酞普兰的辅助药物使用后,抑郁症状和促炎标志物的变化。
方法 100 名患者随机分配至西酞普兰 (20 mg/天) 加安慰剂 (每日两次) (n=50) 或西酞普兰 (20 mg/天) 加 PTX (400 mg) (每日两次) (n=50)。评估基线、第 2、4、6、8、10 和 12 周的汉密尔顿抑郁量表-17 (HAM-D-17) 评分以及基线和第 12 周的血清白细胞介素 1-β (IL-1-β)、肿瘤坏死因子-α、C 反应蛋白、IL-6、血清素、IL-10 和脑源性神经营养因子 (BDNF) 水平。
结果 PTX 组在第 4、6、8、10 和 12 周后的 HAM-D-17 评分与对照组相比显著降低((LSMD):分别为 -2.193,p=0.021;-2.597,p=0.036;-2.916,p=0.019;-4.336,p=0.005;和 -4.087,p=0.008)。与安慰剂组相比,接受 PTX 治疗的患者反应(83%)和缓解率(79%)更好(分别为 49% 和 40%,p=0.006 和 p=0.01)。此外,PTX 组血清促炎因子浓度降低以及血清素和 BDNF 增加显著高于安慰剂组(p<0.001)。
结论 这些研究结果支持 PTX 作为 MDD 患者具有抗炎作用的辅助抗抑郁药物的安全性和有效性。
Original Paper
Llorca-Bofí, Vicent; Bioque, Miquel; Madero, Santiago; Mallorquí, Andrea; Oliveira, Cristina; Garriga, Marina; Parellada, Eduard; García-Rizo, Clemente:
Blood Cell Count Ratios at Baseline are Associated with Initial Clinical Response to Clozapine in Treatment-Resistant, Clozapine-Naïve, Schizophrenia-Spectrum Disorder
Meszár, Viktória; Magyar, Gabriella; Pásztor, Gabriella Mészárosné; Szatmári, Balázs; Péter, Krisztina; Marton, Lívia; Dombi, Zsófia B.; Barabássy, Ágota:
Cariprazine Orodispersible Tablet: A New Formulation for Cariprazine
Takahashi, Yuna; Yatomi, Taisuke; Yamaguchi, Naohito; Yoshimura, Kimio; Hori, Satoko; Uchida, Hiroyuki:
Comparable Psychotropic Prescription Rates After Hospital Discharge Between Patients with COVID-19 and Those With Non-COVID-19-Related Respiratory Infection
Maier, Hannah B.; Borchert, Anton; Neyazi, Alexandra; Moschny, Nicole; Schülke, Rasmus; Bundies, Gabriel L.; Folsche, Thorsten; Gaspert, Anastasia; Seifert, Johanna; Bleich, Stefan; Scherf-Clavel, Maike; Unterecker, Stefan; Deckert, Jürgen; Frieling, Helge; Weber, Heike:
Risk Phenotypes, Comorbidities, Pharmacotherapy, and Electroconvulsive Therapy (ECT) in a Cohort with Difficult-to-Treat Depression in Comparison to an Unmedicated Control Group
Merza Mohammad, Talar A.; Merza Mohammad, Tavgah A.; Salman, Dyar M.; Jaafar, Halmat M.
Pentoxifylline as a Novel Add-on Therapy for Major Depressive Disorder in Adult Patients: A Randomized, Double-Blind, Placebo-Controlled Trial