银盐将醛在温和条件下氧化为羧酸的反应。
3-Chlorosalicylic acid (2). To AgNO3 (8.5 g, 50 mmol) in 50 mL H2O was added to NaOH (2.2 g, 55 mmol) in 5 mL H2O. Ag2O was filtered, washed (water), suspended in 10% NaOH (100 mL) and heated to 60–65 C. 2-Hydroxy-3-chlorobenzaldehyde 1 (7.83 g, 50 mmol) was added slowly. After
30–40 min, the mixture was filtered and the filtrate acidified to pH 4. Crystallization from water gave 7.75 g of 2 (90%), mp 178 C.
【Hamson Rl, Org Synth Coll Vol, 1963, IV, 493, 919, 972】
相关文献
1 Delepine M Bull Soc Chem Fr 1909 5 879
2 Hamson Rl Org Synth Coll Vol 1963 IV 493, 919, 972
3 Sha W Molecules 2008 13 948
4 Chakraborty D Tet Lett 2009 50 6553
相关反应
编译自：Organic Syntheses Based On Name Reactions, 3RdEd, A. Hassner, Page 121.
