Exploring mass transfer as a parameter in mechanochemical processes
Obida Bawadkji* and Rainer Haag
👉 This study reveals that optimizing mass transfer through a novel ball-mill medium design significantly enhances mechanochemical synthesis efficiency, offering a more controlled and scalable approach to green chemistry.
Halogen-bonded cocrystals via resonant acoustic mixing
Alireza Nari, Jeffrey S. Ovens and David L. Bryce*
👉 Resonant acoustic mixing (RAM) is shown to be an effective mechanochemical method for producing halogen-bonded cocrystals, characterized here by X-ray diffraction and solid-state NMR. An elusive stoichiomorph unobtainable by milling is found via RAM.
Jingbo Yu,*（俞静波，浙江工业大学） Yanhua Zhang, Zehao Zheng, and Weike Su*（苏为科，浙江工业大学）
👉 A new three-step mechano-synthesis method starts with 4-bromoquinoline, uses Suzuki–Miyaura, Minisci C–H alkylation, and oxidation Heck coupling reactions, leading to rapid and eco-friendly synthesis of the key Pitavastatin intermediate.
Direct arylation of alkyl fluorides using in situ mechanochemically generated calcium-based heavy Grignard reagents
Pan Gao, Julong Jiang, Yamato Fukuzawa, Satoshi Maeda, Koji Kubota* and Hajime Ito*
👉 Here, we report the reaction of calcium-based heavy Grignard reagents, which are easily generated by a mechanochemical method, with unactivated alkyl fluorides to produce the arylated products in moderate to good yields.
