顶尖学者介绍｜阿尔兹海默病专业知识领域Top6-10的大牛们都有谁？速看！-第二期

1.        阿尔茨海默病中的淀粉样蛋白-β 通路：通俗易懂的语言总结

Hampel, H., Hu, Y., Hardy, J., Blennow, K., Chen, C., Perry, G., Kim, S. H., Villemagne, V. L., Aisen, P., Vendruscolo, M., Iwatsubo, T., Masters, C. L., Cho, M., Lannfelt, L., Cummings, J. L., & Vergallo, A. (2023). The amyloid-β pathway in Alzheimer's disease: a plain language summary. Neurodegenerative disease management, 13(3), 141–149. https://doi.org/10.2217/nmt-2022-0037

2.        神经病学和精神病学精准医学的基础和结构

Hampel, H., Gao, P., Cummings, J., Toschi,
N., Thompson, P. M., Hu, Y., Cho, M., & Vergallo, A. (2023). The foundation
and architecture of precision medicine in neurology and psychiatry.Trends
in neurosciences, 46(3), 176–198.
https://doi.org/10.1016/j.tins.2022.12.004

3.        批准的乙酰胆碱酯酶抑制剂治疗阿尔茨海默氏病反应结果的决定因素：与神经退行性疾病精准医学的相关性

Lista, S., Vergallo, A., Teipel, S. J.,
Lemercier, P., Giorgi, F. S., Gabelle, A., Garaci, F., Mercuri, N. B.,
Babiloni, C., Gaire, B. P., Koronyo, Y., Koronyo-Hamaoui, M., Hampel, H.,
Nisticò, R., & Neurodegeneration Precision Medicine
Initiative (NPMI) (2023). Determinants of approved acetylcholinesterase
inhibitor response outcomes in Alzheimer's disease: relevance for precision
medicine in neurodegenerative diseases. Ageing research reviews, 84,
101819. https://doi.org/10.1016/j.arr.2022.101819

4.        纠正：轻度认知障碍 MRI 亚型对多奈哌齐的不同反应

Diaz-Galvan, P., Lorenzon, G., Mohanty, R.,
Mårtensson, G., Cavedo, E., Lista, S., Vergallo, A., Kantarci, K., Hampel, H.,
Dubois, B., Grothe, M. J., Ferreira, D., & Westman, E. (2023). Correction:
Differential response to donepezil in MRI subtypes of mild cognitive
impairment.Alzheimer's research & therapy, 15(1), 177.
https://doi.org/10.1186/s13195-023-01320-8

5.        更年期激素治疗显着改变阿尔茨海默病的病理生理生物标志物

Depypere, H., Vergallo, A., Lemercier, P.,
Lista, S., Benedet, A., Ashton, N., Cavedo, E., Zetterberg, H., Blennow, K.,
Vanmechelen, E., Hampel, H., & Neurodegeneration Precision Medicine
Initiative (NPMI) (2023). Menopause hormone therapy significantly alters
pathophysiological biomarkers of Alzheimer's disease.Alzheimer's &
dementia : the journal of the Alzheimer's Association, 19(4), 1320–1330. https://doi.org/10.1002/alz.12759

6.        遗忘症轻度认知障碍患者的磁共振成像蓝斑异常与未来进展为痴呆有关

Galgani, A., Lombardo, F., Martini, N.,
Vergallo, A., Bastiani, L., Hampel, H., Hlavata, H., Baldacci, F., Tognoni, G.,
De Marchi, D., Ghicopulos, I., De Cori, S., Biagioni, F., Busceti, C.L.,
Ceravolo, R., Bonuccelli, U., Chiappino, D., Siciliano, G., Fornai, F., Pavese,
N., & Giorgi, F.S. (2022). Magnetic resonance imaging Locus Coeruleus
abnormality in amnestic Mild Cognitive Impairment is associated with future
progression to dementia.European Journal of Neurology, 30, 32 - 46.

7.        基于生物机制的神经病学和精神病学：BACE1/2 和下游通路模型

Hampel, H., Caruso, G., Nisticò, R., Piccioni, G., Mercuri, N. B., Giorgi, F. S., Ferrarelli, F.,
Lemercier, P., Caraci, F., Lista, S., Vergallo, A., & Neurodegeneration
Precision Medicine Initiative Npmi (2023). Biological Mechanism-based Neurology
and Psychiatry: A BACE1/2 and Downstream Pathway Model. Current
neuropharmacology, 21(1), 31–53.
https://doi.org/10.2174/1570159X19666211201095701

8.        设计阿尔茨海默病的下一代临床护理途径

Hampel, H., Au, R., Mattke, S., van der
Flier, W. M., Aisen, P., Apostolova, L., Chen, C., Cho, M., De Santi, S., Gao,
P., Iwata, A., Kurzman, R., Saykin, A. J., Teipel, S., Vellas, B., Vergallo,
A., Wang, H., & Cummings, J. (2022). Designing the next-generation clinical
care pathway for Alzheimer's disease.Nature aging, 2(8), 692–703. https://doi.org/10.1038/s43587-022-00269-x

9.        用于描述阿尔茨海默病生物学变化的 AT(N) 系统：简单的语言摘要

SuiHampel, H., Elhage, A., Cummings, J., Blennow, K., Gao, P., Jack, C. R.,
Jr, & Vergallo, A. (2022). The AT(N) system for describing biological
changes in Alzheimer's disease: a plain language summary. Neurodegenerative
disease management, 12(5), 231–239.
https://doi.org/10.2217/nmt-2022-0013

10.       腰椎穿刺在阿尔茨海默氏病中的使用和安全建议：通俗易懂的语言总结

Hampel, H., Elhage, A., Shaw, L. M., Aisen,
P., Chen, C., Lleó, A., Iwatsubo, T., Iwata, A.,
Yamada, M., Ikeuchi, T., Jia, J., Wang, H., Teunissen, C. E., Peskind, E.,
Blennow, K., Cummings, J., & Vergallo, A. (2022). The use of lumbar
puncture and safety recommendations in Alzheimer's disease: a plain language
summary. Neurodegenerative disease management, 12(5), 221–229. https://doi.org/10.2217/nmt-2022-0012

1.       阿尔茨海默病的外周特征，具有微生物群-肠-脑轴标记物

Marizzoni, M., Mirabelli, P., Mombelli, E., Coppola, L., Festari, C., Lopizzo, N., Luongo, D., Mazzelli, M., Naviglio, D., Blouin, J. L., Abramowicz, M., Salvatore, M., Pievani, M., Cattaneo, A., & Frisoni, G. B. (2023). A peripheral signature of Alzheimer's disease featuring microbiota-gut-brain axis markers.Alzheimer's research & therapy, 15(1), 101. https://doi.org/10.1186/s13195-023-01218-5

2.       早期与晚期淀粉样蛋白正电子发射断层扫描对记忆诊所患者的临床效果：AMYPAD-DPMS 随机临床试验

Altomare, D., Barkhof, F., Caprioglio, C.,
Collij, L. E., Scheltens, P., Lopes Alves, I., Bouwman, F., Berkhof, J., van
Maurik, I. S., Garibotto, V., Moro, C., Delrieu, J., Payoux, P., Saint-Aubert,
L., Hitzel, A., Molinuevo, J. L., Grau-Rivera, O., Gispert, J. D., Drzezga, A.,
Jessen, F., … Amyloid Imaging to Prevent Alzheimer’s Disease (AMYPAD) Consortium (2023). Clinical Effect of Early vs
Late Amyloid Positron Emission Tomography in Memory Clinic Patients: The
AMYPAD-DPMS Randomized Clinical Trial. JAMA neurology, 80(6), 548–557. https://doi.org/10.1001/jamaneurol.2023.0997

3.       阿尔茨海默病的血浆生物标志物：记忆诊所的现场测试

Altomare, D., Stampacchia, S., Ribaldi, F.,
Tomczyk, S., Chevalier, C., Poulain, G., Asadi, S., Bancila, B., Marizzoni, M.,
Martins, M., Lathuiliere, A., Scheffler, M., Ashton, N. J., Zetterberg, H.,
Blennow, K., Kern, I., Frias, M., Garibotto, V., & Frisoni, G. B. (2023).
Plasma biomarkers for Alzheimer's disease: a field-test in a memory
clinic.Journal of neurology, neurosurgery, and psychiatry, 94(6),
420–427. https://doi.org/10.1136/jnnp-2022-330619

4.       阿尔茨海默病的结果衡量标准: 全球社会间的德尔菲共识

Ellison, T. S., Cappa, S. F., Garrett, D.,
Georges, J., Iwatsubo, T., Kramer, J. H., Lehmann, M., Lyketsos, C., Maier, A.
B., Merrilees, J., Morris, J. C., Naismith, S. L., Nobili, F., Pahor, M., Pond,
D., Robinson, L., Soysal, P., Vandenbulcke, M., Weber, C. J., Visser, P. J., … Frisoni, G. B. (2023). Outcome measures for Alzheimer's disease: A
global inter-societal Delphi consensus. Alzheimer's & dementia : the
journal of the Alzheimer's Association, 19(6), 2707–2729. https://doi.org/10.1002/alz.12945

5.       向主观认知衰退的成年人公开淀粉样蛋白-正电子发射断层扫描成像结果后的心理症状分析

Caprioglio, C., Ribaldi, F., Visser, L. N.
C., Minguillon, C., Collij, L. E., Grau-Rivera, O., Zeyen, P., Molinuevo, J.
L., Gispert, J. D., Garibotto, V., Moro, C., Walker, Z., Edison, P., Demonet,
J. F., Barkhof, F., Scheltens, P., Alves, I. L., Gismondi, R., Farrar, G.,
Stephens, A. W., … AMYPAD consortium (2023). Analysis
of Psychological Symptoms Following Disclosure of Amyloid-Positron Emission
Tomography Imaging Results to Adults With Subjective Cognitive
Decline. JAMA network open, 6(1), e2250921. https://doi.org/10.1001/jamanetworkopen.2022.50921

6.       阿尔茨海默病的全外显子组稀有变异分析和相关生物标志物特征

Küçükali, F., Neumann, A., Van Dongen, J., De Pooter, T., Joris, G., De
Rijk, P., Ohlei, O., Dobricic, V., Bos, I., Vos, S. J. B., Engelborghs, S., De
Roeck, E., Vandenberghe, R., Gabel, S., Meersmans, K., Tsolaki, M., Verhey, F.,
Martinez-Lage, P., Tainta, M., Frisoni, G., … EMIF-AD
Study Group (2023). Whole-exome rare-variant analysis of Alzheimer's disease
and related biomarker traits. Alzheimer's & dementia : the journal of
the Alzheimer's Association, 19(6), 2317–2331.
https://doi.org/10.1002/alz.12842

7.       单一脑电图 (EEG) 通道可以告诉我们有关轻度认知障碍的阿尔茨海默病患者的哪些信息

Del Percio, C., Lopez, S., Noce, G., Lizio,
R., Tucci, F., Soricelli, A., Ferri, R., Nobili, F., Arnaldi, D., Famà, F., Buttinelli, C., Giubilei, F., Marizzoni, M., Güntekin, B., Yener, G., Stocchi, F., Vacca, L., Frisoni, G. B., &
Babiloni, C. (2023). What a Single Electroencephalographic (EEG) Channel Can
Tell us About Alzheimer's Disease Patients With Mild Cognitive
Impairment. Clinical EEG and neuroscience, 54(1), 21–35. https://doi.org/10.1177/15500594221125033

8.       阿尔茨海默病的概率模型：淀粉样蛋白假说的修订

Frisoni, G. B., Altomare, D., Thal, D. R.,
Ribaldi, F., van der Kant, R., Ossenkoppele, R., Blennow, K., Cummings, J., van
Duijn, C., Nilsson, P. M., Dietrich, P. Y., Scheltens, P., & Dubois, B.
(2022). The probabilistic model of Alzheimer disease: the amyloid hypothesis
revised.Nature reviews. Neuroscience, 23(1), 53–66. https://doi.org/10.1038/s41583-021-00533-w

9.       低剂量脑部照射可使 TSPO 和 CLUSTERIN 水平正常化，并促进症状前 TgF344-AD 大鼠的非淀粉样蛋白生成途径

Ceyzériat, K.,
Zilli, T., Millet, P., Koutsouvelis, N., Dipasquale, G., Fossey, C., Cailly,
T., Fabis, F., Frisoni, G. B., Garibotto, V., & Tournier, B. B. (2022).
Low-dose brain irradiation normalizes TSPO and CLUSTERIN levels and promotes
the non-amyloidogenic pathway in pre-symptomatic TgF344-AD rats. Journal
of neuroinflammation, 19(1), 311.
https://doi.org/10.1186/s12974-022-02673-x

10.    单个脑电图 (EEG) 通道可以告诉我们有关阿尔茨海默氏病痴呆症患者的信息

Del Percio, C., Noce, G., Lopez, S., Tucci,
F., Carlin, G., Lizio, R., Musat, A.M., Soricelli, A., Salvatore, M., Ferri,
R., Nobili, F., Arnaldi, D., Famà, F., Buttinelli, C., Giubilei, F., Marizzoni,
M., Güntekin, B., Yener, G.G., Stocchi, F., Vacca, L., Frisoni, G.B., &
Babiloni, C. (2022). What a single electroencephalographic (EEG) channel can
tell us about patients with dementia due to Alzheimer's
disease.International journal of psychophysiology : official journal of
the International Organization of Psychophysiology, 182, 169-181 .

1.     每个细胞的神经退行性疾病

Balusu, S., Praschberger, R., Lauwers, E., De Strooper, B., & Verstreken, P. (2023). Neurodegeneration cell per cell.Neuron, 111(6), 767–786. https://doi.org/10.1016/j.neuron.2023.01.016

2.       MCH 系统的早期改变将阿尔茨海默病小鼠模型的异常神经元活动和睡眠障碍联系起来。

Calafate, S., Özturan, G., Thrupp, N.,
Vanderlinden, J., Santa-Marinha, L., Morais-Ribeiro, R., Ruggiero, A., Bozic,
I., Rusterholz, T., Lorente-Echeverría, B., Dias, M.,
Chen, W. T., Fiers, M., Lu, A., Vlaeminck, I., Creemers, E., Craessaerts, K.,
Vandenbempt, J., van Boekholdt, L., Poovathingal, S., …de Wit, J. (2023). Early alterations in the MCH system link aberrant neuronal
activity and sleep disturbances in a mouse model of Alzheimer's
disease. Nature neuroscience, 26(6), 1021–1031.
https://doi.org/10.1038/s41593-023-01325-4

3.       PSEN1-γ-分泌酶复合物的选择性抑制剂

Serneels, L., Narlawar, R., Perez-Benito,
L., Municoy, M., Guallar, V., T'Syen, D., Dewilde, M., Bischoff, F., Fraiponts,
E., Tresadern, G., Roevens, P. W. M., Gijsen, H. J. M., & De Strooper, B.
(2023). Selective inhibitors of the PSEN1-gamma-secretase complex.The
Journal of biological chemistry, 299(6), 104794.
https://doi.org/10.1016/j.jbc.2023.104794

4.       Wnt信号调节因子dkk2的小胶质细胞表达在阿尔茨海默病人大脑和小鼠神经退行性疾病模型之间差异

Aghaizu, N. D., Jolly, S., Samra, S. K.,
Kalmar, B., Craessaerts, K., Greensmith, L., Salinas, P. C., De Strooper, B.,
& Whiting, P. J. (2023). Microglial Expression of the Wnt Signaling
ModulatorDKK2 Differs between Human Alzheimer's Disease Brains and
Mouse Neurodegeneration Models. eNeuro, 10(1), ENEURO.0306-22.2022.
https://doi.org/10.1523/ENEURO.0306-22.2022

5.       阿尔茨海默病中的细胞死亡: 小胶质细胞、星形胶质细胞和神经元的细胞类型特异性激活

Zivony, Moonen, S., Koper, M. J., Van Schoor, E.,
Schaeverbeke, J. M., Vandenberghe, R., von Arnim, C. A. F., Tousseyn, T., De
Strooper, B., & Thal, D. R. (2023). Pyroptosis in Alzheimer's disease: cell
type-specific activation in microglia, astrocytes and neurons. Acta
neuropathologica, 145(2), 175–195.
https://doi.org/10.1007/s00401-022-02528-y

6.       血浆生物标志物和遗传学在阿尔茨海默病的诊断和预测中的应用

Stevenson-Hoare, J., Heslegrave, A.,
Leonenko, G., Fathalla, D., Bellou, E., Luckcuck, L., Marshall, R., Sims, R.,
Morgan, B. P., Hardy, J., de Strooper, B., Williams, J., Zetterberg, H., &
Escott-Price, V. (2023). Plasma biomarkers and genetics in the diagnosis and
prediction of Alzheimer's disease.Brain : a journal of
neurology, 146(2), 690–699.
https://doi.org/10.1093/brain/awac128

7.       阿尔茨海默病的淀粉样蛋白假说：新疗法的新见解

Karran, E., & De Strooper, B. (2022).
The amyloid hypothesis in Alzheimer disease: new insights from new
therapeutics.Nature reviews. Drug discovery, 21(4), 306–318. https://doi.org/10.1038/s41573-022-00391-w

8.       LATE-NC 会加重阿尔茨海默病中 GVD 介导的坏死性死亡 

Koper, M. J., Tomé,
S. O., Gawor, K., Belet, A., Van Schoor, E., Schaeverbeke, J., Vandenberghe,
R., Vandenbulcke, M., Ghebremedhin, E., Otto, M., von Arnim, C. A. F., Balusu,
S., Blaschko, M. B., De Strooper, B., & Thal, D. R. (2022). LATE-NC
aggravates GVD-mediated necroptosis in Alzheimer's disease. Acta
neuropathologica communications, 10(1), 128.
https://doi.org/10.1186/s40478-022-01432-6

9.       星形胶质细胞钙功能障碍导致阿尔茨海默病的早期网络过度活跃

Shah, D., Gsell, W., Wahis, J., Luckett, E.
S., Jamoulle, T., Vermaercke, B., Preman, P., Moechars, D., Hendrickx, V.,
Jaspers, T., Craessaerts, K., Horré, K., Wolfs, L.,
Fiers, M., Holt, M., Thal, D. R., Callaerts-Vegh, Z., D'Hooge, R.,
Vandenberghe, R., Himmelreich, U., … De Strooper, B.
(2022). Astrocyte calcium dysfunction causes early network hyperactivity in
Alzheimer's disease. Cell reports, 40(8), 111280.
https://doi.org/10.1016/j.celrep.2022.111280

10.    AAV 介导的抗 BACE1 VHH 递送可减轻阿尔茨海默病模型的病理学

Marino, M., Zhou, L., Rincon, M. Y.,
Callaerts-Vegh, Z., Verhaert, J., Wahis, J., Creemers, E., Yshii, L., Wierda,
K., Saito, T., Marneffe, C., Voytyuk, I., Wouters, Y., Dewilde, M., Duqué, S. I., Vincke, C., Levites, Y., Golde, T. E., Saido, T. C.,
Muyldermans, S., … Holt, M. G. (2022). AAV-mediated
delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease
model. EMBO molecular medicine, 14(4), e09824.
https://doi.org/10.15252/emmm.201809824

1.       增加 AD 研究参与者的多样性：阿尔茨海默病神经影像计划中的数字筛查、血液检测和社区参与方法计划4

Weiner, M. W., Veitch, D. P., Miller, M. J., Aisen, P. S., Albala, B., Beckett, L. A., Green, R. C., Harvey, D., Jack, C. R., Jr, Jagust, W., Landau, S. M., Morris, J. C., Nosheny, R., Okonkwo, O. C., Perrin, R. J., Petersen, R. C., Rivera-Mindt, M., Saykin, A. J., Shaw, L. M., Toga, A. W., … Alzheimer's Disease Neuroimaging Initiative (2023). Increasing participant diversity in AD research: Plans for digital screening, blood testing, and a community-engaged approach in the Alzheimer's Disease Neuroimaging Initiative 4. Alzheimer's & dementia : the journal of the Alzheimer's Association, 19(1), 307–317. https://doi.org/10.1002/alz.12797

2.       PSEN1致病变异体的定位影响常染色体显性阿尔茨海默氏病的认知、临床和神经退行性疾病的进展

Schultz SA, Shirzadi Z, Schultz AP, Liu L,
Fitzpatrick CD, McDade E, Barthelemy NR, Renton A, Esposito B, Joseph-Mathurin
N, Cruchaga C, Chen CD, Goate A, Allegri RF, Benzinger TLS, Berman S, Chui HC,
Fagan AM, Farlow MR, Fox NC, Gordon BA, Day GS, Graff-Radford NR, Hassenstab
JJ, Hanseeuw BJ, Hofmann A, Jack CR Jr, Jucker M, Karch CM, Koeppe RA, Lee JH,
Levey AI, Levin J, Martins RN, Mori H, Morris JC, Noble J, Perrin RJ, Rosa-Neto
P, Salloway SP, Sanchez-Valle R, Schofield PR, Xiong C, Johnson KA, Bateman RJ,
Sperling RA, Chhatwal JP; Dominantly Inherited Alzheimer Network Investigators.
Location of pathogenic variants in PSEN1 impacts progression of cognitive,
clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's
disease. Aging Cell. 2023 Aug;22(8):e13871. doi: 10.1111/acel.13871. Epub 2023
Jun 8. PMID: 37291760; PMCID: PMC10410059.

3.       用于预测阿尔茨海默病神经病理变化的血浆生物标志物

Bermudez C, Graff-Radford J, Syrjanen JA,
Stricker NH, Algeciras-Schimnich A, Kouri N, Kremers WK, Petersen RC, Jack CR
Jr, Knopman DS, Dickson DW, Nguyen AT, Reichard RR, Murray ME, Mielke MM,
Vemuri P. Plasma biomarkers for prediction of Alzheimer's disease
neuropathologic change. Acta Neuropathol. 2023 Jul;146(1):13-29. doi:
10.1007/s00401-023-02594-w. Epub 2023 Jun 3. PMID: 37269398; PMCID:
PMC10478071.

4.       脑血管疾病与阿尔茨海默病成像生物标志物之间存在时间关联的证据

Cogswell, P. M., Lundt, E. S., Therneau, T.
M., Mester, C. T., Wiste, H. J., Graff-Radford, J., Schwarz, C. G., Senjem, M.
L., Gunter, J. L., Reid, R. I., Przybelski, S. A., Knopman, D. S., Vemuri, P.,
Petersen, R. C., & Jack, C. R., Jr (2023). Evidence against a temporal
association between cerebrovascular disease and Alzheimer's disease imaging
biomarkers.Nature communications, 14(1), 3097.
https://doi.org/10.1038/s41467-023-38878-8

5.       阿尔茨海默病中与Tau沉积相关的白质退化途径

Tian, J., Raghavan, S., Reid, R. I.,
Przybelski, S. A., Lesnick, T. G., Gebre, R. K., Graff-Radford, J., Schwarz, C.
G., Lowe, V. J., Kantarci, K., Knopman, D. S., Petersen, R. C., Jack, C. R.,
Jr, & Vemuri, P. (2023). White Matter Degeneration Pathways Associated With
Tau Deposition in Alzheimer Disease.Neurology, 100(22), e2269–e2278.
https://doi.org/10.1212/WNL.0000000000207250

6.       脑脊液中神经退行性生物标志物与阿尔茨海默病和血管病理学标志物的关联

Shir, D., Mielke, M. M., Hofrenning, E. I.,
Lesnick, T. G., Knopman, D. S., Petersen, R. C., Jack, C. R.,
Algeciras-Schimnich, A., Vemuri, P., & Graff-Radford, J. (2023).
Associations of Neurodegeneration Biomarkers in Cerebrospinal Fluid with Markers
of Alzheimer's Disease and Vascular Pathology.Journal of Alzheimer's
disease : JAD, 92(3), 887–898.
https://doi.org/10.3233/JAD-221015

7.       利用血浆生物标志物预测淀粉样蛋白 PET 和 tau PET 阶段

Jack, C. R., Wiste, H. J.,
Algeciras-Schimnich, A., Figdore, D. J., Schwarz, C. G., Lowe, V. J., Ramanan,
V. K., Vemuri, P., Mielke, M. M., Knopman, D. S., Graff-Radford, J., Boeve, B.
F., Kantarci, K., Cogswell, P. M., Senjem, M. L., Gunter, J. L., Therneau, T.
M., & Petersen, R. C. (2023). Predicting amyloid PET and tau PET stages
with plasma biomarkers.Brain : a journal of neurology, 146(5), 2029–2044. https://doi.org/10.1093/brain/awad042

8.       早期阿尔茨海默病中pTau231在突触后密度的积累

Lilek, J., Ajroud, K., Feldman, A. Z.,
Krishnamachari, S., Ghourchian, S., Gefen, T., Spencer, C. L., Kawles, A., Mao,
Q., Tranovich, J. F., Jack, C. R., Mesulam, M. M., Reichard, R. R., Zhang, H.,
Murray, M. E., Knopman, D., Dickson, D. W., Petersen, R. C., Smith, B., Ashe,
K. H., … Flanagan, M. E. (2023). Accumulation of
pTau231 at the Postsynaptic Density in Early Alzheimer's Disease. Journal
of Alzheimer's disease : JAD, 92(1), 241–260.
https://doi.org/10.3233/JAD-220848

9.       解读执行障碍性阿尔茨海默病的临床放射学异质性

Corriveau-Lecavalier, N., Barnard, L. R.,
Lee, J., Dicks, E., Botha, H., Graff-Radford, J., Machulda, M. M., Boeve, B.
F., Knopman, D. S., Lowe, V. J., Petersen, R. C., Jack, C. R., Jr, & Jones,
D. T. (2023). Deciphering the clinico-radiological heterogeneity of
dysexecutive Alzheimer's disease.Cerebral cortex (New York, N.Y. :
1991), 33(11), 7026–7043.
https://doi.org/10.1093/cercor/bhad017

10.    通过磁共振弹性成像评估痴呆病因对皮质僵硬度的差异影响

Pavuluri, K., Scott, J. M., Huston Iii, J.,
Ehman, R. L., Manduca, A., Jack, C. R., Jr, Savica, R., Boeve, B. F., Kantarci,
K., Petersen, R. C., Knopman, D. S., & Murphy, M. C. (2023). Differential
effect of dementia etiology on cortical stiffness as assessed by MR
elastography.NeuroImage. Clinical, 37, 103328.
https://doi.org/10.1016/j.nicl.2023.103328

1.       以 5-羟色胺-6受体为靶点，治疗脑部疾病药物的研究进展

Nirogi, R., Jayarajan, P., Shinde, A.,
Mohammed, A. R., Grandhi, V. R., Benade, V., Goyal, V. K., Abraham, R., Jasti,
V., & Cummings, J. (2023). Progress in Investigational Agents Targeting
Serotonin-6 Receptors for the Treatment of Brain Disorders.Biomolecules, 13(2),
309. https://doi.org/10.3390/biom13020309

2.       冷漠与抑郁的区分：神经认知障碍中冷漠与抑郁的行为、神经解剖学和治疗相关方面的区别

Lanctôt, K. L., Ismail, Z., Bawa, K. K.,
Cummings, J. L., Husain, M., Mortby, M. E., & Robert, P. (2023).
Distinguishing apathy from depression: A review differentiating the behavioral,
neuroanatomic, and treatment-related aspects of apathy from depression in
neurocognitive disorders.International journal of geriatric
psychiatry, 38(2), e5882. https://doi.org/10.1002/gps.5882

3.       神经病学和精神病学精准医学的基础和结构

Hampel, H., Gao, P., Cummings, J., Toschi,
N., Thompson, P. M., Hu, Y., Cho, M., & Vergallo, A. (2023). The foundation
and architecture of precision medicine in neurology and psychiatry.Trends
in neurosciences, 46(3), 176–198.
https://doi.org/10.1016/j.tins.2022.12.004

4.       皮质厚度与阿尔茨海默病患者的认知运动自动性和注意力分配有关：一项感兴趣的研究区域

Longhurst, J. K., Sreenivasan, K. R., Kim,
J., Cummings, J. L., John, S. E., Poston, B., Cordes, D., Rider, J. V., &
Landers, M. R. (2023). Cortical thickness is related to cognitive-motor
automaticity and attention allocation in individuals with Alzheimer's disease:
a regions of interest study.Experimental brain research, 241(6),
1489–1499. https://doi.org/10.1007/s00221-023-06618-5

5.       抗淀粉样蛋白单克隆抗体是重新定义阿尔茨海默病治疗的变革性治疗方法

Cummings J. (2023). Anti-Amyloid Monoclonal
Antibodies are Transformative Treatments that Redefine Alzheimer's Disease
Therapeutics.Drugs, 83(7), 569–576. https://doi.org/10.1007/s40265-023-01858-9

6.       阿尔茨海默病与肠道微生物群的遗传相关性

Cammann, D., Lu, Y., Cummings, M. J.,
Zhang, M. L., Cue, J. M., Do, J., Ebersole, J., Chen, X., Oh, E. C., Cummings,
J. L., & Chen, J. (2023). Genetic correlations between Alzheimer's disease
and gut microbiome genera.Scientific reports, 13(1), 5258.
https://doi.org/10.1038/s41598-023-31730-5

7.       Verubecestat APECS 研究中从前驱阿尔茨海默病到轻度阿尔茨海默病痴呆的进展：裁定诊断转变

Voss, T., Kost, J., Mercer, S. P., Furtek,
C., Randolph, C., Lines, C., Egan, M. F., & Cummings, J. L. (2023).
Progression from Prodromal Alzheimer's Disease to Mild Alzheimer's Disease
Dementia in the Verubecestat APECS Study: Adjudicating Diagnostic
Transitions.Journal of Alzheimer's disease : JAD, 92(1), 341–348. https://doi.org/10.3233/JAD-220836

8.       以人群为基础的发现和孟德尔随机化分析确定替米沙坦是治疗非裔美国人阿尔茨海默病的候选药物

Zhang, P., Hou, Y., Tu, W., Campbell, N.,
Pieper, A. A., Leverenz, J. B., Gao, S., Cummings, J., & Cheng, F. (2023).
Population-based discovery and Mendelian randomization analysis identify
telmisartan as a candidate medicine for Alzheimer's disease in African
Americans.Alzheimer's & dementia : the journal of the Alzheimer's
Association, 19(5), 1876–1887. https://doi.org/10.1002/alz.12819

9.       六名前美国橄榄球运动员临终前氟脱氧葡萄糖正电子发射断层扫描(PET)与死后CTE相关tau神经病理学的关系

Alosco, M. L., Su, Y., Stein, T. D.,
Protas, H., Cherry, J. D., Adler, C. H., Balcer, L. J., Bernick, C., Pulukuri,
S. V., Abdolmohammadi, B., Coleman, M. J., Palmisano, J. N., Tripodis, Y., Mez,
J., Rabinovici, G. D., Marek, K. L., Beach, T. G., Johnson, K. A., Huber, B.
R., Koerte, I., … DIAGNOSE C. T. E. Research Project
(2023). Associations between near end-of-life flortaucipir PET and postmortem
CTE-related tau neuropathology in six former American football
players. European journal of nuclear medicine and molecular
imaging, 50(2), 435–452.
https://doi.org/10.1007/s00259-022-05963-x