Title: Solid-like Merlin Condensates In The Hippo Signaling Pathway
09:00 am – 10:00 am
16 October 2024 (Wednesday)
Zoom ID: 999 5737 0847
Passcode: 748555
ABSTRACT
The Hippo pathway has emerged as an evolutionarily conserved signaling network that regulates cell proliferation, tissue homeostasis, and tissue regeneration. We show that the tumor suppressor Merlin, an upstream regulator of the Hippo pathway, forms solid-like condensates that activate Hippo signaling in Drosophila tissues. Merlin condensation required phosphatidylinositol-4-phosphate (PI4P)-mediated plasma membrane targeting, and was antagonistically controlled by Pez and cytoskeletal tension through plasma membrane PI4P regulation. The solid-like material properties of Merlin condensates are essential for physiological function and protect the condensates against external perturbations.
BIOGRAPHY
Dr. Pengfei Guo is an Associate Research Professor at the School of Life Sciences, Westlake University. He obtained his Ph.D. from Peking University/National Institute of Biological Sciences, Beijing in 2011 under the supervision of Dr. Xiaochen Wang. In 2012, he joined the laboratory of Professor Duojia Pan at Johns Hopkins University School of Medicine for postdoctoral training. In 2024, he joined Professor Kunliang Guan’s lab at Westlake University as an Associate Research Professor. Dr. Guo's research focuses on uncovering the molecular mechanisms that regulate animal tissue growth and development. His work has been published in journals including Science, eLife, and PNAS.
来源：生命科学与生物医学工程学域
欢迎联系咨询
↓↓
系统枢纽
gzsystems@hkust-gz.edu.cn
生命科学与生物医学工程博士申请咨询
bsbe@hkust-gz.edu.cn
智能交通博士申请咨询
intr@hkust-gz.edu.cn
机器人与自主系统博士申请咨询
roas@hkust-gz.edu.cn
智能制造博士申请咨询
smmg@hkust-gz.edu.cn
关注系统枢纽
及时获取新鲜资讯
长按二维码关注
系统枢纽微信公众号
长按二维码进入
系统枢纽微信视频号
微博搜索关注
@港科大广州系统枢纽
小红书搜索关注
@港科大广州系统枢纽
知乎搜索关注
@港科大广州系统枢纽
B站搜索关注
@港科大广州系统枢纽
今日头条搜索关注
@港科大广州系统枢纽
抖音搜索关注
@港科大广州系统枢纽
Join Zoom Meeting
