可穿戴电子设备是持续、长期和远程健康监测的重要趋势。然而，大多数现有的可穿戴电子设备只能感知皮肤表面或皮肤表面以下 1 厘米的浅层组织的信号。然而，在深层组织中，即皮肤表面下 1 厘米以上的组织中，有更多的事件发生。通常，这些深层组织信号与疾病状态和进展的相关性比表面信号更强、更快。现有的可穿戴电子设备只能捕捉到冰山一角。皮肤下还有很大的空间。
加利福尼亚大学圣迭戈分校的 Sheng Xu 团队通过开发一种可穿戴的超声波贴片，重塑了超声波诊断。该贴片由超声换能器阵列、背衬层和匹配层组成，通过可拉伸金属丝相互连接，并封装在弹性体中。该贴片与人体皮肤一样顺滑，可连续佩戴 24 小时以上，且不会对皮肤造成任何刺激。已将可穿戴超声波贴片用于监测许多现有可穿戴设备无法监测到的深层组织信号。
1. 使用共形超声贴片进行经颅容积成像
Transcranial volumetric imaging using a conformal ultrasound patch
Nature 629, 810–818 (2024)
https://www.nature.com/articles/s41586-024-07381-5
2. 用于监测移动对象深层组织的全集成可穿戴超声系统
A fully integrated wearable ultrasound system to monitor deep tissues in moving subjects
Nature Biotechnology 42, 448–457 (2024)
https://www.nature.com/articles/s41587-023-01800-0
3. 可穿戴超声技术的临床、安全和工程视角：综述
Clinical, safety and engineering perspectives on wearable ultrasound technology: A review
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
DOI: 10.1109/TUFFC.2023.3342150 (2024)
4. 新兴可穿戴超声技术
Emerging wearable ultrasound technology
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
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In-ear integrated sensor array for the continuous monitoring of brain activity and of lactate in sweat
Nature Biomedical Engineering 7, 1307–1320 (2023)
https://www.nature.com/articles/s41551-023-01095-1
6. 用于三维绘制深层组织模量的可拉伸超声阵列
Stretchable ultrasonic arrays for the three-dimensional mapping of the modulus of deep tissue
Nature Biomedical Engineering 7, 1321–1334 (2023)
https://www.nature.com/articles/s41551-023-01038-w
7. 柔性传感器技术路线图
Technology roadmap for flexible sensors
ACS Nano 17, 5211-5295 (2023)
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8. 可穿戴式心脏超声成像仪
A wearable cardiac ultrasound imager
Nature 613, 667-675 (2023)
https://www.nature.com/articles/s41586-022-05498-z
9. 用于血红蛋白和核心温度三维成像的光声贴片
A photoacoustic patch for three-dimensional imaging of hemoglobin and core temperature
Nature Communications 13, 7757 (2022)
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Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays
Nature Biomedical Engineering 5, 749-758 (2021)
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