近日，PLANT CELL ENVIRON发表了由山东农大朱常香、竺晓平为通讯作者的研究论文《Non-Specific Lipid Transfer Protein StLTP6 Promotes Virus Infection by Inhibiting Jasmonic Acid Signalling Pathway in Response to PVS TGB1》，揭示了非特异性脂质转运蛋白LTP6通过抑制响应PVS TGB1的茉莉酸信号通路促进病毒感染。
植物病毒的成功感染依赖于宿主因子。非特异性脂质转移蛋白（nsLTPs）在植物-病原体相互作用中起着关键作用；然而，它们在病毒感染中的功能和潜在的分子机制在很大程度上仍然未知。
茉莉酸（JA）是植物抵抗病毒感染过程中至关重要的调节激素。在这项研究中，作者筛选并验证了先前鉴定的pro-viral factor，StLTP6与马铃薯S病毒（PVS）的沉默抑制三重基因块1（TGB1）相互作用。
PVS TGB1诱导StLTP6的表达，两者共定位于细胞质中。此外，StLTP6与丙二烯环化酶相互作用并抑制其积累，从而抑制JA合成并减弱RNA沉默的抗病毒活性。
总之，作者阐明了PVS TGB1与StLTP6相互作用以促进PVS感染的分子机制。这些发现拓宽了我们对nsLTPs生物学作用的理解，并为马铃薯生物学研究提供了新的抗病毒靶点。
Plant viruses rely on host factors for successful infection. Non-specific lipid transfer proteins (nsLTPs) play critical roles in plant−pathogen interactions; however, their functions and underlying molecular mechanisms in viral infections remain largely unknown. Jasmonic acid (JA) is a crucial regulatory hormone in the process of plant resistance to viral infection. In this study, we screened and verified that StLTP6, a previously identified pro-viral factor, interacts with the silencing suppressor triple gene block1 (TGB1) of potato virus S (PVS). The PVS TGB1 induces the expression of StLTP6, and both co-localize in the cytoplasm. Furthermore, StLTP6 interacts with allene oxide cyclase and inhibits its accumulation, thereby suppressing JA synthesis and attenuating RNA silencing antiviral resistance. In summary, we elucidated the molecular mechanism by which PVS TGB1 interacts with StLTP6 to facilitate PVS infection. These findings broaden our understanding of the biological roles of nsLTPs and provide a new antiviral target for potato research.
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