(最新)12名全奖博士/博士后——荷兰格罗宁根大学生物物理,生物化学,生物工程,分子生物方向招聘

时尚   2024-10-08 09:29   加拿大  



更多学术职位请查阅网站 https://6emails.com/ 中的Jobs专栏


12 PhD/Post doc positions for the design and engineering of synthetic cells


Building a synthetic cell is one of the greatest scientific and technological challenges of the 21st century. In the framework of a huge national Dutch program (EVOLF, https://www.evolf.life) and a European Doctorate network (ComeInCell, https://www.comeincell.org), we have 12 PhD/Postdoc positions available for biophysicists, bioengineers, biochemists, and molecular biologist at the Groningen Biomolecular Sciences and Biotechnology Institute (https://www.rug.nl/research/gbb) of the University of Groningen in the Netherlands.

The positions are available in five different research groups for either computational or experimental research: (i) to experimentally reconstruct reaction networks for metabolic energy and synthesis of cellular building blocks; (ii) to build synthetic cell-like systems for autonomous operation and growth, or (iii) to develop computational models at different levels of complexity to generate designs of synthetic cells.

Positions

Poolman group (https://membraneenzymology.com)

  • Position 1: Design and construction of reaction networks. We will integrate in bacteria-size vesicles metabolic modules essential for life. Further reading: doi: 10.1038/s41467-024-52085-z

  • Position 2: Membrane expansion in synthetic cells. We will expand the membrane of cell-like systems through the coupling of lipid transport to lipid synthesis and volume regulation. Further reading: doi: 10.1021/acssynbio.4c00073

  • Position 3: Evolution and integration of metabolic modules. We will evolve and couple reaction networks through genome design, selection, performance screening and AI. Further reading: doi.org/10.21203/rs.3.rs-3990950/v1

  • Position 4: Compartmentalization and spatial distribution of reaction networks in synthetic cells. We will exploit the properties of biomolecular condensates to enhance the efficiency of reaction networks for fuel supply and building block synthesis. Further reading: doi: 10.1038/s42003-024-06216-3

  • Position 5: Membrane expansion with condensates. We will combine active membrane expansion with the expression of synthetic RNA condensates to engineer complex re-structuring events such as engulfment, exocytosis, membrane rupture and/or fission. Further reading: doi: 10.1126/sciadv.abd7697

Heinemann group (www.heinemannlab.eu)

  • Position 6: To equip synthetic cells with ATP, NADH and amino acids, we will establish a synthetic, bottom-up built glycolysis in vesicles. We will in vitro assemble – in a stepwise manner – a functional glycolytic pathway and optimize it. To this end, high-end mass spectrometric analyses will be used as well as a mathematical model of glycolysis earlier developed by the group.

  • Position 7: To equip synthetic cells with ATP, NADH and amino acids, we will establish a synthetic, bottom-up built glycolysis in vesicles. We will engineer a synthetic operon for this pathway and optimize it through in vivo evolution. In a stepwise manner, we will build such synthetic operon on a plasmid and delete the respective genes on the E. coli chromosome. We will use evolution and targeted gene mutation strategies to optimize the plasmid-expressed pathway.

Slotboom group (https://membraneenzymology.com)

  • Position 8: To equip synthetic cells with multiple metabolic pathways, innovative reconstitution and organization methods are needed. We will explore protein scaffolds, membrane-bound and membrane-less compartments, rational and AI-based engineering to obtain efficient fluxes through multiple pathways in the same synthetic cell. https://doi.org/10.1021/acssynbio.3c00062

  • Position 9: To equip synthetic cells with membrane-associated processes (such as solute transport), a membrane protein insertion machinery is needed. We will identify a minimal insertion machinery and optimize it for efficient insertion of functional transporters, using biochemical and biophysical assays. doi: 10.1093/synbio/ysae007

Kamenz group (kamenzlab.com)

  • Position 10: For a synthetic cell to continuously divide, cell growth and cell division have to be tightly regulated and temporally separated. We will combine protein biochemistry, directed evolution and mathematical modeling to develop a synthetic oscillator and the necessary control modules to drive periodic cycles of cell growth and division. Further reading: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796343/

Marrink group (cgmartini.nl)

  • Position 11: Multiscale modeling of cell division, probing the interplay between lipids and proteins for the rational design of efficient fission of artificial cells. Further reading: https://doi.org/10.1038/s41467-020-16094-y

  • Position 12: Molecular dynamics simulations of minimal cells, focusing on the properties and organization of the cell envelope. Further reading: https://doi.org/10.3389/fchem.2023.1106495

Requirements

•      Enthusiasm, excellence, commitment to research and team spirit are our key selection criteria.

•      Educational backgrounds are preferably in the area of biochemistry, bioengineering, biophysics, molecular biology or comparable.

•      Candidates for a PhD position need to have completed a Master’s degree (or equivalent). Postdoctoral candidates need to have completed their PhD.

•      Excellent proficiency in English language.

Conditions

Each position can be either filled by a PhD student (with a four-year contract) or a postdoc (with a three-year contract). Salaries will be commensurate with experience and include a generous fringe benefit package. Starting dates are flexible. Yet, a preferred starting date is within the first six months of 2025.

How to apply

To apply for one (or more) of the positions, apply here https://6emails.com/job/12-phd-post-doc-positions-for-the-design-and-engineering-of-synthetic-cells/ 

Application deadline: December 1, 2024.



回顾往期精彩内容



本人PhD的平凡之路......

2021CSC公派留学全程分享「从套磁到派出」,干货满满。送给正在准备申请CSC的你

我的GPA 太低了,怎么继续申请国外项目?

爱丁堡大学两位博导对于博士申请的几点建议

教授访谈系列【2】 宾夕法尼亚大学教授告诉你申请中哪些坑不能踩

哎,CSC今年没中,我真的很差吗?还有后路可言吗?

2022年国家留学基金委第十三届国际研究生奖学金信息说明会回顾(全程2个多小时)

在德国留学一定不能做的7件事儿(英文和德文字幕)

在意大利生活不可以做的14件事情

在苏黎世联邦理工(ETH)读书,需要的日常费用是多少,内含各种省钱小妙招

雷区还是圆满?读研究生时能不能把孩子也生了?耶鲁学姐来告诉你所有的答案



 
HELLO_today2021 

top 20top 50  top 100 


!

每日更新全奖国外申请资讯
每天专注于更新国外及国内港澳台地区硕博,博士后的全奖/奖学金申请信息,望各位早早都能拿到自己心仪的offer。该公众号同时会发布雅思,托福,GRE 等真题考试内容及课程,谢谢关注!
 最新文章