Drug Research
Issue 08 · Volume 74 · October 2024
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Singh V et al.
Evaluation of the Efficacy of Tofacitinib, a JAK Inhibitor, in Alleviating Sepsis-Induced Multiple Organ Dysfunction Syndrome
脓毒症是一种由不受控制的感染反应引发的危及生命的疾病，会导致全身炎症反应综合征 (SIRS) 和多器官衰竭，从而导致多器官功能障碍 (MODS)。在本研究中，我们使用盲肠结扎穿刺 (CLP) 诱发的小鼠模型研究了托法替尼 (TOFA)（FDA 批准的 JAK1 和 JAK3 抑制剂）治疗脓毒症的潜力。使用瑞士白化小鼠复制 CLP 诱发的脓毒症模型，并将其随机分为四组：对照组、CLP、150 mg/kg TOFA 和 300 mg/kg TOFA。最后一次 TOFA 给药六小时后，我们从肝脏、肺、肾和脾脏采集血液和组织样本进行组织学分析。血液样本用于评估粒细胞和淋巴细胞百分比。在整个实验过程中，我们监测体重和短期生存率。我们的比较组织学分析显示，150 mg/kg TOFA 对多器官损伤具有保护作用。相反，该研究强调了 300 mg/kg TOFA 的有害影响，主要是由于该组内的肝脏和肾脏毒性。总之，我们的研究结果表明，最佳剂量 150 mg/kg 的托法替尼有望成为败血症引起的多器官衰竭的潜在治疗干预措施。然而，在考虑更高剂量时需要谨慎。
Review
Bisht, Manoj; Kadian, Jai Parkash; Hooda, Tanuj; Jain, Neelam; Lather, Amit; Aggarwal, Navidha:
Explore the Role of the Sphingosine-1-Phosphate Signalling as a Novel Promising Therapeutic Target for the Management of Parkinson's Disease
Original Article
Figueroa, Lauro; Rosas, Marcela; Alvarez, Magdalena; Aguilar, Emilio; Mateu, Virginia; Bonilla, Enrique:
Interaction of Purine and its Derivatives with A1, A2-Adenosine Receptors and Vascular Endothelial Growth Factor Receptor-1 (Vegf-R1) as a Therapeutic Alternative to Treat Cancer
Singh, Vaishnavi; Joshi, Kavita; Chatterjee, Samit; Qureshi, Sameer; Siddh, Snigdha; Nunia, Vandana:
Evaluation of the Efficacy of Tofacitinib, a JAK Inhibitor, in Alleviating Sepsis-Induced Multiple Organ Dysfunction Syndrome
Mousavi-Nasab, Kian; Amani, Mohammad; Mostafalou, Sara:
The Effect of Trientine on AlCl3-Induced Cognitive Dysfunction and Biochemical Changes in the Hippocampus of Rats
Saha, Sonali; Kalita, Kongkana; Dhinsa, Kavita; Arora, Deval Kumar; Godhi, Brinda Suhas; Doddawad, Vidya Gowdappa:
Antibacterial Efficacy of Hiora: An Ayurvedic Mouthwash in Children
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DOI: 10.1055/s-00023610
