三联复方制剂GMRx2的疗效和安全性
三联降压治疗 vs. 四药复方制剂,哪种降压效果更好?
治疗8周后,四药复方制剂组诊室收缩压比三联治疗组多降低了8.04 mmHg,二者分别平均降低20.67 mmHg和11.32 mmHg。
四药复方制剂组的24小时动态收缩压比三联治疗组多降低了7.53 mmHg。
四药复方制剂组诊室舒张压比三联治疗组多降低了6.14 mmHg。
四药复方制剂组和三联治疗组分别有66.3%和42.7%的患者达到临床血压控制(<140/90 mmHg); 四药复方制剂组和三联治疗组分别有51.2%和20.7%的患者24小时动态血压恢复正常(24小时平均血压<130/80 mmHg); 四药复方制剂组和三联治疗组分别有60.7%和25.4%的患者家庭血压恢复正常(<135/85 mmHg)。
小结
[1]Novel low-dose triple single-pill combination shows efficacy and tolerability in two international trials. https://www.escardio.org/The-ESC/Press-Office/Press-releases/Novel-low-dose-triple-single-pill-combination-shows-efficacy-and-tolerability-in-two-international-trials
[2] Ojji DB, Salam A et al. Comparison of Low-Dose Triple Pill and Standard Care Protocols for Hypertension Treatment in Black Africans in Nigeria: A Randomised Clinical Trial. JAMA. 2024. https://doi.org/10.1001/jama.2024.18080
[3]A single tablet with 4 blood pressure-lowering drugs can be more effective than taking 3 drugs in separate pills. https://www.escardio.org/The-ESC/Press-Office/Press-releases/A-single-tablet-with-4-blood-pressure-lowering-drugs-can-be-more-effective-than-taking-3-drugs-in-separate-pills