博后 | 北欧 EMBL 与芬兰赫尔辛基大学博士后合作项目

    Title:    Call for Applications in NORPOD Collaborative Postdoctoral     Programme by Nordic EMBL Partnership for Molecular Medicine

    Employer:   University of Helsinki

    Location:   Yliopistonkatu 4 Helsinki, Finland

    Gaustadaléen 21 Oslo, Norway

    Biomedicine Building 6K and 6L, University Hospital of Umeå Umeå,     Sweden

    Published:   2024-12-11

    Application deadline:  2025-01-24 23:59 (Europe/Helsinki)

    2025-01-24 22:59 (CET)

    Job type:    Postdoc

We invite applications for three NORPOD postdoctoral fellowship projects. The projects are offered as collaborations between two Nordic EMBL supervisors (PIs) across the nodes of the Nordic EMBL Partnership. Each project has two supervisors. One supervisor will host the NORPOD Fellow at his/her node’s host university, while collaborating with a co-supervisor from a different Nordic EMBL node. 

As a NORPOD Fellow, you will develop a collaborative project under the supervision of two Nordic EMBL PIs at two different sites. You will obtain a 30-month, full time postdoctoral employment at the institution of the hosting supervisor.

As a NORPOD Fellow you will travel for short or long-term stays to the collaborating supervisor's lab to promote collaboration and carry out parts of the research project. You will gain access to state-of-the-art core facilities and platforms available in the wider network of the Nordic EMBL Partnership. You also participate and contribute to strengthening your personal and professional development. You will advance the goals of the Nordic EMBL Partnership by fostering synergies and research excellence. 

For comprehensive information on the NORPOD program’s all projects, explore the NORPOD program page.

Project 1: Genetic and adaptive dynamics of microbiome in colorectal cancer: How do microbes adapt to the hostile tumour microenvironment? (ADAPT-MIC)

Nordic EMBL PIs: Rafa Najumudeen (FIMM) and Chinmay Dwibedi (MIMS)

Current research in the cancer microbiome highlights the interaction between gut microbes and the host in tumor progression, but the adaptation of these microbes to the tumor's hostile microenvironment remains poorly understood. This project aims to identify the spatial genetic and adaptive dynamics of tumour microbiome in colorectal cancer. To do so, we will integrate single-cell genomics, transcriptomics and clinical data using unique novel mouse models, spatial technologies and analytical methods.

Host institution and employment: FIMM, University of Helsinki, Finland

Collaborating site: MIMS, Umeå University, Sweden

Find all information and apply here.

Project 2: Novel insights into the cancer genome and epigenome using long-read sequencing and machine learning

Nordic EMBL PIs: Esa Pitkänen (FIMM) and Biswajyoti Sahu (NCMM)

Human tumors are characterized by recurrent mutations in the well-defined cancer driver genes, but also non- mutational epigenetic reprogramming and phenotypic plasticity controlled by transcription factors are important contributors to tumorigenesis. We will utilize cutting-edge long-read nanopore sequencing combined with deep machine learning approaches to model the epigenetic changes and mutational mechanisms in cancers originating from endodermal tissues. The project aims to reveal novel mechanistic details about the development of human cancer.

Host institution and employment: FIMM, University of Helsinki, Finland

Collaborating site: NCMM, University of Oslo, Norway

Find all information and apply here. 

Project 3: Revealing the epigenetic history of colon cancer progression (REVEAL)

Nordic EMBL PIs: Biswajyoti Sahu (NCMM) and Rafa Najumudeen (FIMM)

Colorectal cancers (CRC) are driven by complex genetic and epigenetic changes that enable cancer cells to adapt to their dynamic environment. We aim to uncover the epigenetic mechanisms underlying colon cancer initiation, progression, and therapy resistance by using genome scale Massively Parallel Reporter Assays in organoid models to identify key transcription factors and cis-regulatory elements driving oncogenic processes. After validation of these findings, we will record the epigenetic reprogramming in vivo. Our approach integrates genomic and epigenomic technologies to map the temporal epigenetic history of colon cancer.

Host institution and employment: NCMM, University of Oslo, Norway

Collaborating site: FIMM, University of Helsinki, Finland

Find all information and apply here. 

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