Regulation of chamber-specific mammalian cardiomyocyte polyploidization
Summary
FULLY FUNDED PHD POSITION IN CARDIOMYOCYTE BIOLOGY
Cardiomyocyte polyploidization, i.e., multiplication of the genome, is prevalent across mammals, happens typically postnatally, and negatively correlates with the regenerative capacity of the heart. Despite 40 years of discovery, HOW and WHY mammalian cardiomyocytes become polyploid remained poorly understood.
Our recent findings showed that cardiomyocyte polyploidization is regulated in a chamber-specific manner. Transcriptomic analyzes further revealed interesting differences in the composition of non-myocytes (e.g., immune cells and endothelium) as well as the extracellular matrix between the left atrium, right atrium, and the ventricle in the postnatal mouse heart. Building on these and other findings, we are looking for a motivated PhD candidate to join our team at the European Center for Angioscience to investigate how intercellular interactions regulates chamber-specific cardiomyocyte polyploidization.
What we offer:
- Friendly and inclusive working environment
- Young and dynamic team
- State-of-art facilities
- Ample collaboration opportunities with local and international experts in cardiovascular research, developmental biology, transcriptional control and epigenetics, and data science
- Support in career development
Your profile:
- Strong interest in developmental and regeneration biology.
- Excellent communication skills (English).
- Ability to work independently and in a team.
- Creativity and critical thinking.
- Prior experiences with primary cultures, mouse genetics, and FELASA qualification are desirable but not necessary.
** Applications will be reviewed on a rolling-basis until positions are filled **
Methods that will be used
Primary cultures, OMICs, mouse and zebrafish models
Keywords
cardiomyocyte biology, heart regeneration, cell cycle
Application Link: https://my-hbigs.uni-heidelberg.de/site/index.php?a=RVB4MnpHLzZ1UGZQNnFGSDRNYXRPUklDUXpMZEhpQUVwcGhjWXkzUDFVVE83ZWRvT0JNM3VTNlVZbWlSdWk0c2ZuNWtkSm9VM1B4VWM1clpVWmY3TzM1K1pIU2FGTno4VkhPYTJWR1grenRMZE80SzBpTHEyRWlISVZTMVBMdmg%3D
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