About this Research Topic
The cell fate map depicts the fate of cells, the developmental stage of embryos, and which cells or regions will produce which tissues. The purpose of lineage tracing is to construct a hierarchical structure of individual cells producing offspring. At present, novel embryo bioengineering technology, genetic recombination tools, and single-cell genome sequencing methods can objectively evaluate cell identity, capturing thousands of gene expression measurements while maintaining the cell resolution required for accurate lineage reconstruction. The advancement of genetics and genomics has led to the rapid development of lineage tracing strategies, making it possible to construct complex lineage relationship trees in developmental systems.
Thus, the current aims of this Research Topic are to collate articles on embryonic cell fate mapping. We encourage interested investigators to submit review articles and original research that aim to promote the research progress of early embryonic development lineage by applying advanced embryonic or genetic methods, such as embryo transfer, gene manipulation, Cre or FLP recombinases, single cell or spatial sequencing.
Differentiation patterns of early embryonic cell lineages and their genetic or metabolic regulatory mechanisms.
Molecular mechanisms of embryonic germ layer differentiation and organ formation.
Genetic markers for cell lineage tracing.
Novel technologies to promote the efficiency of cell lineage tracing.
Interaction between embryonic cell lineage and developmental disorders (e.g. congenital cardiovascular and neurological diseases)
Manuscript Summary Submission Deadline 04 February 2025
Manuscript Submission Deadline 25 May 2025
详细信息：https://www.frontiersin.org/research-topics/68333/early-embryonic-development-lineage
