Biomed Pharmacother
2017 Jun:90:278-286.
doi: 10.1016/j.biopha.2017.03.068. Epub 2017 Mar 30.
MiR-370 functions as oncogene in melanoma by direct targeting pyruvate dehydrogenase B
Shufang Wei 1, Weiyuan Ma 2
Affiliations expand
PMID: 28364600
DOI: 10.1016/j.biopha.2017.03.068
Retraction in
Retraction notice to 'MiR-370 functions as oncogene in melanoma by direct targeting pyruvate dehydrogenase B' [Biomedicine & Pharmacotherapy, Volume 90 (2017) Pages 278-286].
Wei S, Ma W.Biomed Pharmacother. 2024 Sep;178:117168. doi: 10.1016/j.biopha.2024.117168. Epub 2024 Jul 21.PMID: 39039009 No abstract available.
Abstract
Background: Accumulating evidence has shown that miR-370 play an important role in the development and progression of tumor. However, the role of miR-370 in melanoma remains largely unknown. The present study is designed to investigate the function of miR-370 in melanoma and to explore the molecular mechanism underlying its function.
Materials and methods: The expression level of miR-370 was detected in melanoma tissues and cell lines by real-time quantitative polymerase chain reaction (qRT-PCR). The effect of overexpression of miR-370 on in vitro cell proliferation, apoptosis, invasion as well as glyclolysis was examined. Western blotting analysis was used to detect the influence of miR-370 on the expression of target genes, and Pearson analysis was used to calculate the correlation between the expression of targets gene and miR-370 in melanoma tissues.
Results: Our study showed that miR-370 was upregulated in melanoma tissues compared with non-cancerous tissues (P<0.01). In addition, the expression of miR-370 in melanoma cell lines was also significantly higher (P<0.01). Enforced expression of miR-370 promotes melanoma cell proliferation, inhibits apoptosis and enhances invasion and glycolysis and led to downregulation of the PDHB protein. Moreover, the expression level of miR-370 in melanoma tissues showed inverse relationship with the expression level of PDHB protein.
Conclusions: In conclusion, our findings suggested that miR-370 represents a potential oncogenic miRNA and plays an important role in melanoma progression by directly targeting PDHB.
Keywords: Melanoma; MiR-370; PDHB.
参考链接：https://pubpeer.com/publications/D98A4CF1B3CB2F451D2AFE453BAF75
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